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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-Tubulin Beta 3 Class III Rabbit Monoclonal Antibody
KD-Validated Anti-Tubulin Beta 3 Class III Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC |
|---|---|
| Primary Accession | Q13509 |
| Reactivity | Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB1740 |
| Calculated MW | Predicted, 50 kDa , observed , 55 kDa |
| Gene Name | TUBB3 |
| Aliases | TUBB3; Tubulin Beta 3 Class III; CFEOM3A; Beta-4; CFEOM3; Class III Beta-Tubulin; Tubulin Beta-3 Chain; Tubulin Beta-4 Chain; Tubulin Beta-III; Tubulin, Beta 3; FEOM3; TUBB4; Fibrosis Of Extraocular Muscles, Congenital, 3; CDCBM1; CDCBM |
| Immunogen | A synthesized peptide derived from human beta Tubulin III |
| Gene ID | 10381 |
|---|---|
| Other Names | Tubulin beta-3 chain, Tubulin beta-4 chain, Tubulin beta-III, TUBB3, TUBB4 |
| Name | TUBB3 |
|---|---|
| Synonyms | TUBB4 |
| Function | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:34996871, PubMed:38305685, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:34996871, PubMed:38305685, PubMed:38609661). Below the cap, alpha-beta tubulin heterodimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). TUBB3 plays a critical role in proper axon guidance and maintenance (PubMed:20074521). Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Plays a role in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977). |
| Cellular Location | Cytoplasm, cytoskeleton. Cell projection, growth cone {ECO:0000250|UniProtKB:Q9ERD7}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q9ERD7}. Cell projection, filopodium {ECO:0000250|UniProtKB:Q9ERD7} |
| Tissue Location | Expression is primarily restricted to central and peripheral nervous system. Greatly increased expression in most cancerous tissues. |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI1713
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