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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-SLC25A12 Rabbit Monoclonal Antibody
KD-Validated Anti-SLC25A12 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC |
|---|---|
| Primary Accession | O75746 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB2340 |
| Calculated MW | Predicted, 75 kDa , observed , 72 kDa |
| Gene Name | SLC25A12 |
| Aliases | SLC25A12; Solute Carrier Family 25 Member 12; Aralar; AGC1; Electrogenic Aspartate/Glutamate Antiporter SLC25A12, Mitochondrial; Aralar1; Solute Carrier Family 25 (Mitochondrial Carrier, Aralar), Member 12; Solute Carrier Family 25 (Aspartate/Glutamate Carrier), Member 12; Mitochondrial Aspartate Glutamate Carrier 1; Aspartate/Glutamate Carrier 1; Araceli Hiperlarga; Calcium Binding Mitochondrial Carrier Superfamily Member Aralar1; Calcium-Binding Mitochondrial Carrier Protein Aralar1; ARALAR1; EIEE39; DEE39 |
| Immunogen | A synthesized peptide derived from human SLC25A12 |
| Gene ID | 8604 |
|---|---|
| Other Names | Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial, Araceli hiperlarga, Aralar, Aralar1, Mitochondrial aspartate glutamate carrier 1, Solute carrier family 25 member 12 {ECO:0000312|HGNC:HGNC:10982}, SLC25A12 (HGNC:10982) |
| Name | SLC25A12 (HGNC:10982) |
|---|---|
| Function | Mitochondrial electrogenic aspartate/glutamate antiporter that favors efflux of aspartate and entry of glutamate and proton within the mitochondria as part of the malate-aspartate shuttle (PubMed:11566871, PubMed:19641205, PubMed:24515575, PubMed:38945283). Also mediates the uptake of L-cysteinesulfinate (3-sulfino-L-alanine) by mitochondria in exchange of L-glutamate and proton (PubMed:11566871). Can also exchange L-cysteinesulfinate with aspartate in their anionic form without any proton translocation (PubMed:11566871). Lacks transport activity towards L-glutamine or gamma-aminobutyric acid (GABA) (PubMed:38945283). |
| Cellular Location | Mitochondrion inner membrane; Multi-pass membrane protein |
| Tissue Location | Expressed predominantly in the heart and skeletal muscle, weakly in brain and kidney. |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI1727
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