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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-UBE2T Rabbit Monoclonal Antibody
KD-Validated Anti-UBE2T Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | Q9NPD8 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB2350 |
| Calculated MW | Predicted, 23 kDa , observed , 23 kDa |
| Gene Name | UBE2T |
| Aliases | UBE2T; Ubiquitin Conjugating Enzyme E2 T; HSPC150; FANCT; Cell Proliferation-Inducing Gene 50 Protein; Ubiquitin-Conjugating Enzyme E2 T; E2 Ubiquitin-Conjugating Enzyme T; Ubiquitin Carrier Protein T; Ubiquitin-Protein Ligase T; HSPC150 Protein Similar To Ubiquitin-Conjugating Enzyme; Ubiquitin-Conjugating Enzyme E2T (Putative); Ubiquitin-Conjugating Enzyme E2T; Ubiquitin Conjugating Enzyme E2T; EC 2.3.2.23; PIG50 |
| Immunogen | A synthesized peptide derived from human HSPC150 |
| Gene ID | 29089 |
|---|---|
| Other Names | Ubiquitin-conjugating enzyme E2 T, 2.3.2.23, Cell proliferation-inducing gene 50 protein, E2 ubiquitin-conjugating enzyme T, Ubiquitin carrier protein T, Ubiquitin-protein ligase T, UBE2T |
| Name | UBE2T |
|---|---|
| Function | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair. Acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway (PubMed:16916645, PubMed:17938197, PubMed:19111657, PubMed:19589784, PubMed:28437106). Also mediates monoubiquitination of FANCL and FANCI (PubMed:16916645, PubMed:17938197, PubMed:19111657, PubMed:19589784). May contribute to ubiquitination and degradation of BRCA1 (PubMed:19887602). In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11'-, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination (PubMed:20061386). |
| Cellular Location | Nucleus. Note=Accumulates to chromatin |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI1729
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