KD-Validated Anti-U2AF2 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application ![]()
| WB, FC, ICC |
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Primary Accession | P26368 |
Reactivity | Rat, Human, Mouse |
Clonality | Monoclonal |
Isotype | Rabbit IgG |
Clone Names | 24GB2465 |
Calculated MW | Predicted, 54 kDa , observed , 54 kDa |
Gene Name | U2AF2 |
Aliases | U2AF2; U2 Small Nuclear RNA Auxiliary Factor 2; U2AF65; U2 SnRNP Auxiliary Factor Large Subunit; U2 Small Nuclear Ribonucleoprotein Auxiliary Factor (65kD); U2 (RNU2) Small Nuclear RNA Auxiliary Factor 2; Splicing Factor U2AF 65 KDa Subunit; U2 Auxiliary Factor 65 KDa Subunit; HU2AF65; Splicing Factor U2AF 65 KD Subunit; HU2AF(65); DEVDFB |
Immunogen | A synthesized peptide derived from human U2AF65 |
Gene ID | 11338 |
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Other Names | Splicing factor U2AF 65 kDa subunit, U2 auxiliary factor 65 kDa subunit, hU2AF(65), hU2AF65, U2 snRNP auxiliary factor large subunit, U2AF2, U2AF65 |
Name | U2AF2 |
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Synonyms | U2AF65 |
Function | Plays a role in pre-mRNA splicing and 3'-end processing (PubMed:17024186). By recruiting PRPF19 and the PRP19C/Prp19 complex/NTC/Nineteen complex to the RNA polymerase II C-terminal domain (CTD), and thereby pre-mRNA, may couple transcription to splicing (PubMed:21536736). Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon 10. Positively regulates pre-mRNA 3'-end processing by recruiting the CFIm complex to cleavage and polyadenylation signals (PubMed:17024186). |
Cellular Location | Nucleus. |

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