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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-Ubiquitin Specific Peptidase 5 Rabbit Monoclonal Antibody
KD-Validated Anti-Ubiquitin Specific Peptidase 5 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | P45974 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB2480 |
| Calculated MW | Predicted, 96 kDa , observed , 100 kDa |
| Gene Name | USP5 |
| Aliases | USP5; Ubiquitin Specific Peptidase 5; Isopeptidase T; IsoT; Ubiquitin-Specific-Processing Protease 5; Ubiquitin Carboxyl-Terminal Hydrolase 5; Deubiquitinating Enzyme 5; Ubiquitin Thioesterase 5; Ubiquitin-Specific Protease-5 (Ubiquitin Isopeptidase T); Ubiquitin Specific Peptidase 5 (Isopeptidase T); Ubiquitin Specific Protease 5 (Isopeptidase T); Testicular Tissue Protein Li 218; Ubiquitin Thiolesterase 5; Ubiquitin Isopeptidase T; EC 3.4.19.12; EC 3.1.2.15; ISOT |
| Immunogen | A synthesized peptide derived from human USP5 |
| Gene ID | 8078 |
|---|---|
| Other Names | Ubiquitin carboxyl-terminal hydrolase 5, 3.4.19.12, Deubiquitinating enzyme 5, Isopeptidase T, Ubiquitin thioesterase 5, Ubiquitin-specific-processing protease 5, USP5, ISOT |
| Name | USP5 |
|---|---|
| Synonyms | ISOT |
| Function | Deubiquitinating enzyme that participates in a wide range of cellular processes by specifically cleaving isopeptide bonds between ubiquitin and substrate proteins or ubiquitin itself. Affects thereby important cellular signaling pathways such as NF-kappa-B, Wnt/beta- catenin, and cytokine production by regulating ubiquitin-dependent protein degradation. Participates in the activation of the Wnt signaling pathway by promoting FOXM1 deubiquitination and stabilization that induces the recruitment of beta-catenin to Wnt target gene promoter (PubMed:26912724). Regulates the assembly and disassembly of heat-induced stress granules by mediating the hydrolysis of unanchored ubiquitin chains (PubMed:29567855). Promotes lipopolysaccharide-induced apoptosis and inflammatory response by stabilizing the TXNIP protein (PubMed:37534934). Affects T-cell biology by stabilizing the inhibitory receptor on T-cells PDC1 (PubMed:37208329). Acts as a negative regulator of autophagy by regulating ULK1 at both protein and mRNA levels (PubMed:37607937). Acts also as a negative regulator of type I interferon production by simultaneously removing both 'Lys-48'-linked unanchored and 'Lys-63'-linked anchored polyubiquitin chains on the transcription factor IRF3 (PubMed:39761299). Modulates the stability of DNA mismatch repair protein MLH1 and counteracts the effect of the ubiquitin ligase UBR4 (PubMed:39032648). Upon activation by insulin, it gets phosphorylated through mTORC1-mediated phosphorylation to enhance YTHDF1 stability by removing 'Lys-11'-linked polyubiquitination (PubMed:39900921). May also deubiquitinate other substrates such as the calcium channel CACNA1H (By similarity). |
| Cellular Location | Cytoplasm. Cytoplasm, Stress granule. Nucleus |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI1747
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