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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-TARBP2 Rabbit Monoclonal Antibody
KD-Validated Anti-TARBP2 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | Q15633 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB2425 |
| Calculated MW | Predicted, 39 kDa , observed , 39 kDa |
| Gene Name | TARBP2 |
| Aliases | TARBP2; TARBP2 Subunit Of RISC Loading Complex; Trbp; TARBP2, RISC Loading Complex RNA Binding Subunit; RISC-Loading Complex Subunit TARBP2; TAR (HIV-1) RNA Binding Protein 2; Trans-Activation Responsive RNA-Binding Protein; Trans-Activation-Responsive RNA-Binding Protein; TAR (HIV) RNA-Binding Protein TRBP1; TAR (HIV) RNA-Binding Protein 2; TAR RNA Binding Protein 2; TAR RNA-Binding Protein 2; TRBP1; TRBP2; LOQS; TRBP |
| Immunogen | A synthesized peptide derived from human TRBP |
| Gene ID | 6895 |
|---|---|
| Other Names | RISC-loading complex subunit TARBP2 {ECO:0000255|HAMAP-Rule:MF_03034}, TAR RNA-binding protein 2, Trans-activation-responsive RNA-binding protein, TARBP2 {ECO:0000255|HAMAP-Rule:MF_03034}, TRBP |
| Name | TARBP2 {ECO:0000255|HAMAP-Rule:MF_03034} |
|---|---|
| Synonyms | TRBP |
| Function | Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1 (By similarity) (PubMed:15973356, PubMed:16142218, PubMed:16271387, PubMed:16357216, PubMed:16424907, PubMed:17452327, PubMed:18178619). Binds in vitro to the PRM1 3'-UTR (By similarity). Seems to act as a repressor of translation (By similarity). For some pre-miRNA substrates, may also alter the choice of cleavage site by DICER1 (PubMed:23063653). Negatively regulates IRF7-mediated IFN-beta signaling triggered by viral infection by inhibiting the phosphorylation of IRF7 and promoting its 'Lys'-48- linked ubiquitination and degradation (PubMed:30927622). |
| Cellular Location | Cytoplasm. Cytoplasm, perinuclear region. Nucleus |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI1754
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