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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-VAMP Associated Protein A Rabbit Monoclonal Antibody
KD-Validated Anti-VAMP Associated Protein A Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | Q9P0L0 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB2580 |
| Calculated MW | Predicted, 28 kDa , observed , 28 kDa |
| Gene Name | VAPA |
| Aliases | VAPA; VAMP Associated Protein A; VAP-A; HVAP-33; VAMP (Vesicle-Associated Membrane Protein)-Associated Protein A, 33kDa; Vesicle-Associated Membrane Protein-Associated Protein A; 33 KDa VAMP-Associated Protein; VAMP-A; VAP-33; VAP33; VAMP (Vesicle-Associated Membrane Protein)-Associated Protein A (33kD); Epididymis Secretory Sperm Binding Protein; VAMP-Associated Protein A |
| Immunogen | A synthesized peptide derived from human VAPA |
| Gene ID | 9218 |
|---|---|
| Other Names | Vesicle-associated membrane protein-associated protein A, VAMP-A, VAMP-associated protein A, VAP-A, 33 kDa VAMP-associated protein {ECO:0000303|Ref.2}, VAP-33, VAPA (HGNC:12648), VAP33 |
| Name | VAPA (HGNC:12648) |
|---|---|
| Synonyms | VAP33 |
| Function | Endoplasmic reticulum (ER)-anchored protein that mediates the formation of contact sites between the ER and endosomes via interaction with FFAT motif-containing proteins such as STARD3 or WDR44 (PubMed:32344433, PubMed:33124732). STARD3-VAPA interaction enables cholesterol transfer from the ER to endosomes (PubMed:33124732). Via interaction with WDR44 participates in neosynthesized protein export (PubMed:32344433). In addition, recruited to the plasma membrane through OSBPL3 binding (PubMed:25447204). The OSBPL3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:25447204). With OSBPL3, may regulate ER morphology (PubMed:16143324). May play a role in vesicle trafficking (PubMed:11511104, PubMed:19289470). |
| Cellular Location | Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Cell membrane; Single-pass type IV membrane protein. Cell junction, tight junction. Nucleus membrane {ECO:0000250|UniProtKB:Q9Z270}. Note=Present in the plasma membrane and in intracellular vesicles, together with SNARE proteins. May also associate with the cytoskeleton. Colocalizes with OCLN at the tight junction in polarized epithelial cells. |
| Tissue Location | Ubiquitous. |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI1766
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