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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-Phospho-eIF2 alpha (Ser51) Rabbit Monoclonal Antibody
KD-Validated Anti-Phospho-eIF2 alpha (Ser51) Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
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Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | P05198 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB3905 |
| Calculated MW | Predicted, 36 kDa, observed, 36 kDa |
| Gene Name | EIF2S1 |
| Aliases | EIF2S1; Eukaryotic Translation Initiation Factor 2 Subunit Alpha; EIF-2alpha; EIF2A; Eukaryotic Translation Initiation Factor 2, Subunit 1 Alpha, 35kDa; Eukaryotic Translation Initiation Factor 2 Subunit 1; EIF-2-Alpha; EIF2-Alpha; EIF-2A; EIF2; Eukaryotic Translation Initiation Factor 2, Subunit 1 (Alpha, 35kD ); EIF-2 |
| Immunogen | A synthesized peptide derived from human Phospho-eIF2 alpha (Ser51) |
| Gene ID | 1965 |
|---|---|
| Other Names | Eukaryotic translation initiation factor 2 subunit 1, Eukaryotic translation initiation factor 2 subunit alpha, eIF-2-alpha, eIF-2A, eIF-2alpha, eIF2-alpha, EIF2S1 (HGNC:3265), EIF2A |
| Name | EIF2S1 (HGNC:3265) |
|---|---|
| Synonyms | EIF2A |
| Function | Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (PubMed:16289705, PubMed:38340717). This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre- initiation complex (43S PIC) (PubMed:16289705). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex (PubMed:16289705). In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B (PubMed:16289705). EIF2S1/eIF2-alpha is a key component of the integrated stress response (ISR), required for adaptation to various stress: phosphorylation by metabolic-stress sensing protein kinases (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2) in response to stress converts EIF2S1/eIF2-alpha in a global protein synthesis inhibitor, leading to an attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activators ATF4 and QRICH1, and hence allowing ATF4- and QRICH1-mediated reprogramming (PubMed:19131336, PubMed:33384352, PubMed:38340717). EIF2S1/eIF2-alpha also acts as an activator of mitophagy in response to mitochondrial damage: phosphorylation by EIF2AK1/HRI promotes relocalization to the mitochondrial surface, thereby triggering PRKN-independent mitophagy (PubMed:38340717). |
| Cellular Location | Cytoplasm, Stress granule {ECO:0000250|UniProtKB:Q6ZWX6}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:P56286}. Mitochondrion. Note=Colocalizes with NANOS3 in the stress granules (By similarity). Relocalizes to the surface of mitochondria in response to mitochondrial damage and phosphorylation by EIF2AK1/HRI (PubMed:38340717). {ECO:0000250|UniProtKB:Q6ZWX6, ECO:0000269|PubMed:38340717} |
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$ 149.00
$ 499.00
Cat# AGI1795
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