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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-Creatine Kinase B type Rabbit Monoclonal Antibody
KD-Validated Anti-Creatine Kinase B type Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | P12277 |
| Reactivity | Rat, Human |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB4355 |
| Calculated MW | Predicted, 43 kDa, observed, 43 kDa |
| Gene Name | CKB |
| Aliases | CKB; Creatine Kinase B; CKBB; Creatine Phosphokinase B-Type; Creatine Kinase Brain-Type; Creatine Kinase B Chain; Creatine Kinase B-Type; Brain Creatine Kinase; EC 2.7.3.2; CPK-B; B-CK; Epididymis Secretory Protein Li; Epididymis Luminal Protein 211; Creatine Kinase, Brain; Creatine Kinase Brain; HEL-S-29; EC 2.7.3; HEL-211; BCK |
| Immunogen | A synthesized peptide derived from human Creatine kinase B type |
| Gene ID | 1152 |
|---|---|
| Other Names | Creatine kinase B-type, 2.7.3.2, Brain creatine kinase, B-CK, Creatine kinase B chain, Creatine phosphokinase B-type, CPK-B, CKB (HGNC:1991), CKBB |
| Name | CKB (HGNC:1991) |
|---|---|
| Synonyms | CKBB |
| Function | Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate) (PubMed:8186255). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (Probable). Acts as a key regulator of adaptive thermogenesis as part of the futile creatine cycle: localizes to the mitochondria of thermogenic fat cells and acts by mediating phosphorylation of creatine to initiate a futile cycle of creatine phosphorylation and dephosphorylation (By similarity). During the futile creatine cycle, creatine and N-phosphocreatine are in a futile cycle, which dissipates the high energy charge of N- phosphocreatine as heat without performing any mechanical or chemical work (By similarity). |
| Cellular Location | Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q04447}. Mitochondrion {ECO:0000250|UniProtKB:Q04447}. Cell membrane. Note=Localizes to the mitochondria of thermogenic fat cells via the internal MTS-like signal (iMTS-L) region {ECO:0000250|UniProtKB:Q04447} |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI1811
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