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> home > Products > Primary Antibodies > Antibody Collections > Prostate negative > KD-Validated Anti-Fibroblast Growth Factor 2 Rabbit Monoclonal Antibody
KD-Validated Anti-Fibroblast Growth Factor 2 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC |
|---|---|
| Primary Accession | P09038 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB4420 |
| Calculated MW | Predicted, 31 kDa, observed, 18-24kDa |
| Gene Name | FGF2 |
| Aliases | FGF2; Fibroblast Growth Factor 2; FGFB; Fibroblast Growth Factor 2 (Basic); Heparin-Binding Growth Factor 2; HBGF-2; FGF-2; BFGF; Basic Fibroblast Growth Factor BFGF; Basic Fibroblast Growth Factor; Prostatropin |
| Immunogen | Recombinant protein of human FGF2 |
| Gene ID | 2247 |
|---|---|
| Other Names | Fibroblast growth factor 2, FGF-2, Basic fibroblast growth factor, bFGF, Heparin-binding growth factor 2, HBGF-2, FGF2, FGFB |
| Name | FGF2 |
|---|---|
| Synonyms | FGFB |
| Function | Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:8663044). Also acts as an integrin ligand which is required for FGF2 signaling (PubMed:28302677). Binds to integrin ITGAV:ITGB3 (PubMed:28302677). Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration (PubMed:28302677, PubMed:8663044). Functions as a potent mitogen in vitro (PubMed:1721615, PubMed:3732516, PubMed:3964259). Can induce angiogenesis (PubMed:23469107, PubMed:28302677). Mediates phosphorylation of ERK1/2 and thereby promotes retinal lens fiber differentiation (PubMed:29501879). |
| Cellular Location | Secreted. Nucleus. Note=Exported from cells by an endoplasmic reticulum (ER)/Golgi-independent mechanism. Unconventional secretion of FGF2 occurs by direct translocation across the plasma membrane (PubMed:20230531). Binding of exogenous FGF2 to FGFR facilitates endocytosis followed by translocation of FGF2 across endosomal membrane into the cytosol (PubMed:22321063). Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as CEP57 (PubMed:22321063) |
| Tissue Location | Expressed in granulosa and cumulus cells. Expressed in hepatocellular carcinoma cells, but not in non-cancerous liver tissue. |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI1817
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