KD-Validated Anti-Integrin alpha V Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application ![]()
| WB, FC, ICC |
---|---|
Primary Accession | P06756 |
Reactivity | Rat, Human, Mouse |
Clonality | Monoclonal |
Isotype | Rabbit IgG |
Clone Names | 24GB4430 |
Calculated MW | Predicted, 116 kDa, observed, 130 kDa |
Gene Name | ITGAV |
Aliases | ITGAV; Integrin Subunit Alpha V; CD51; MSK8; VNRA; VTNR; Integrin, Alpha V (Vitronectin Receptor, Alpha Polypeptide, Antigen CD51); Antigen Identified By Monoclonal Antibody L230; Vitronectin Receptor Subunit Alpha; Vitronectin Receptor; Integrin Alpha-V; Integrin AlphaVbeta3; Integrin, Alpha V; CD51 Antigen |
Immunogen | Recombinant protein of human Integrin alpha V |
Gene ID | 3685 |
---|---|
Other Names | Integrin alpha-V, Vitronectin receptor {ECO:0000312|HGNC:HGNC:6150}, Vitronectin receptor subunit alpha, CD51, Integrin alpha-V heavy chain, Integrin alpha-V light chain, ITGAV (HGNC:6150) |
Name | ITGAV (HGNC:6150) |
---|---|
Function | The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase- 2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1- dependent fractalkine signaling (PubMed:23125415). ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling (PubMed:18441324). ITGAV:ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling (PubMed:28302677). ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:19578119). ITGAV:ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). ITGAV:ITGB3 binds to IL1B and this binding is essential for IL1B signaling (PubMed:29030430). ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGAV:ITGB3 and ITGAV:ITGB6 act as receptors for fibrillin-1 (FBN1) and mediate R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). Integrin alpha-V/beta-6 or alpha- V/beta-8 (ITGAV:ITGB6 or ITGAV:ITGB8) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF- beta-1 activation (PubMed:15184403, PubMed:22278742, PubMed:28117447). ITGAV:ITGB3 acts as a receptor for CD40LG (PubMed:31331973). ITGAV:ITGB3 acts as a receptor for IBSP and promotes cell adhesion and migration to IBSP (PubMed:10640428). |
Cellular Location | Cell membrane; Single-pass type I membrane protein. Cell junction, focal adhesion |

Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.

If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.