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KD-Validated Anti-Integrin alpha V Rabbit Monoclonal Antibody

Rabbit monoclonal antibody

     
  • WB - KD-Validated Anti-Integrin alpha V Rabbit Monoclonal Antibody AGI1819
    Western blotting analysis using anti-integrin subunit alpha V antibody (Cat#AGI1819). Total cell lysates (30 µg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with anti-integrin subunit alpha V antibody (Cat#AGI1819, 1:5,000) and HRP-conjugated goat anti-rabbit secondary antibody respectively.
    detail
  • WB - KD-Validated Anti-Integrin alpha V Rabbit Monoclonal Antibody AGI1819
    Western blotting analysis using anti-integrin subunit alpha V antibody (Cat#AGI1819). Integrin subunit alpha V expression in wild-type (WT) and integrin subunit alpha V (ITGAV) shRNA knockdown (KD) HeLa cells with 20 µg of total cell lysates. Hsp90 α serves as a loading control. The blot was incubated with anti-integrin subunit alpha V antibody (Cat#AGI1819, 1:5,000) and HRP-conjugated goat anti-rabbit secondary antibody respectively.
    detail
  • FC - KD-Validated Anti-Integrin alpha V Rabbit Monoclonal Antibody AGI1819
    Flow cytometric analysis of integrin subunit alpha V expression in HepG2 cells using anti-integrin subunit alpha V antibody (Cat#AGI1819, 1:2,000). Green, isotype control; red, integrin subunit alpha V.
    detail
  • ICC - KD-Validated Anti-Integrin alpha V Rabbit Monoclonal Antibody AGI1819
    Immunocytochemical staining of HepG2 cells with anti-Integrin subunit alpha V antibody(Cat#AGI1819, 1:1,000). Nuclei were stained blue with DAPI; Integrin subunit alpha V was stained magenta with Alexa Fluor® 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Low. Scale bar, 20 µm.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, FC, ICC
Primary Accession P06756
Reactivity Rat, Human, Mouse
Clonality Monoclonal
Isotype Rabbit IgG
Clone Names 24GB4430
Calculated MW Predicted, 116 kDa, observed, 130 kDa
Gene Name ITGAV
Aliases ITGAV; Integrin Subunit Alpha V; CD51; MSK8; VNRA; VTNR; Integrin, Alpha V (Vitronectin Receptor, Alpha Polypeptide, Antigen CD51); Antigen Identified By Monoclonal Antibody L230; Vitronectin Receptor Subunit Alpha; Vitronectin Receptor; Integrin Alpha-V; Integrin AlphaVbeta3; Integrin, Alpha V; CD51 Antigen
Immunogen Recombinant protein of human Integrin alpha V
Additional Information
Gene ID 3685
Other Names Integrin alpha-V, Vitronectin receptor {ECO:0000312|HGNC:HGNC:6150}, Vitronectin receptor subunit alpha, CD51, Integrin alpha-V heavy chain, Integrin alpha-V light chain, ITGAV (HGNC:6150)
Protein Information
Name ITGAV (HGNC:6150)
Function The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase- 2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1- dependent fractalkine signaling (PubMed:23125415). ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling (PubMed:18441324). ITGAV:ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling (PubMed:28302677). ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:19578119). ITGAV:ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). ITGAV:ITGB3 binds to IL1B and this binding is essential for IL1B signaling (PubMed:29030430). ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGAV:ITGB3 and ITGAV:ITGB6 act as receptors for fibrillin-1 (FBN1) and mediate R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). Integrin alpha-V/beta-6 or alpha- V/beta-8 (ITGAV:ITGB6 or ITGAV:ITGB8) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF- beta-1 activation (PubMed:15184403, PubMed:22278742, PubMed:28117447). ITGAV:ITGB3 acts as a receptor for CD40LG (PubMed:31331973). ITGAV:ITGB3 acts as a receptor for IBSP and promotes cell adhesion and migration to IBSP (PubMed:10640428).
Cellular Location Cell membrane; Single-pass type I membrane protein. Cell junction, focal adhesion
Research Areas
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$ 149.00
$ 499.00
Cat# AGI1819
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