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KD-Validated Anti-RAB5A Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC |
|---|---|
| Primary Accession | P20339 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB4520 |
| Calculated MW | Predicted, 24 kDa, observed, 24 kDa |
| Gene Name | RAB5A |
| Aliases | RAB5A; RAB5A, Member RAS Oncogene Family; RAB5; RAS-Associated Protein RAB5A; Ras-Related Protein Rab-5A; EC 3.6.5.2 |
| Immunogen | A synthesized peptide derived from human Rab5 |
| Gene ID | 5868 |
|---|---|
| Other Names | Ras-related protein Rab-5A, 3.6.5.2, RAB5A, RAB5 |
| Name | RAB5A (HGNC:9783) |
|---|---|
| Synonyms | RAB5 |
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes (PubMed:10818110, PubMed:14617813, PubMed:15378032, PubMed:16410077). Contributes to the regulation of filopodia extension (PubMed:14978216). Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan (PubMed:22660413). Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3 (By similarity). |
| Cellular Location | Cell membrane; Lipid-anchor; Cytoplasmic side. Early endosome membrane; Lipid- anchor. Melanosome. Cytoplasmic vesicle. Cell projection, ruffle {ECO:0000250|UniProtKB:P18066}. Membrane Cytoplasm, cytosol. Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:Q9CQD1}. Endosome membrane Note=Enriched in stage I melanosomes (PubMed:17081065). Alternates between membrane-bound and cytosolic forms (Probable) {ECO:0000269|PubMed:17081065, ECO:0000305} |
Research Areas
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Application Protocols
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$ 149.00
$ 499.00
Cat# AGI1827
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