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> home > Products > Primary Antibodies > Antibody Collections > Ovary positive > KD-Validated Anti-Flap Structure-Specific Endonuclease 1 Rabbit Monoclonal Antibody
KD-Validated Anti-Flap Structure-Specific Endonuclease 1 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
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- BACKGROUND
Application 
| WB, FC |
|---|---|
| Primary Accession | P39748 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB4835 |
| Calculated MW | Predicted, 43 kDa, observed, 43 kDa |
| Gene Name | FEN1 |
| Aliases | FEN1; Flap Structure-Specific Endonuclease 1; FEN-1; MF1; DNase IV; RAD2; Maturation Factor-1; Flap Endonuclease 1; Maturation Factor 1; EC 3.1.-.-; HFEN-1 |
| Immunogen | A synthesized peptide derived from human FEN1 |
| Gene ID | 2237 |
|---|---|
| Other Names | Flap endonuclease 1 {ECO:0000255|HAMAP-Rule:MF_03140}, FEN-1 {ECO:0000255|HAMAP-Rule:MF_03140}, 3.1.-.- {ECO:0000255|HAMAP-Rule:MF_03140}, DNase IV, Flap structure-specific endonuclease 1 {ECO:0000255|HAMAP-Rule:MF_03140}, Maturation factor 1, MF1, hFEN-1, FEN1 {ECO:0000255|HAMAP-Rule:MF_03140}, RAD2 |
| Name | FEN1 {ECO:0000255|HAMAP-Rule:MF_03140} |
|---|---|
| Synonyms | RAD2 |
| Function | Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA. |
| Cellular Location | [Isoform 1]: Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI1863
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