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> home > Products > Primary Antibodies > Antibody Collections > SARS-Human interaction partners > KD-Validated Anti-Linker For Activation Of T Cells Rabbit Monoclonal Antibody
KD-Validated Anti-Linker For Activation Of T Cells Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC |
|---|---|
| Primary Accession | O43561 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB4940 |
| Calculated MW | Predicted, 28 kDa,observed, 36 kDa |
| Gene Name | LAT |
| Aliases | LAT; Linker For Activation Of T Cells; LAT1; Linker For Activation Of T Cells,Transmembrane Adaptor; Linker For Activation Of T-Cells Family Member 1; 36 KDa Phosphotyrosine Adapter Protein; P36-38; Pp36; 36 KDa Phospho-Tyrosine Adapter Protein; 36 KDa Phospho-Tyrosine Adaptor Protein; IMD52 |
| Immunogen | A synthesized peptide derived from human LAT |
| Gene ID | 27040 |
|---|---|
| Other Names | Linker for activation of T-cells family member 1, 36 kDa phosphotyrosine adapter protein, pp36, p36-38, LAT |
| Name | LAT |
|---|---|
| Function | Required for TCR (T-cell antigen receptor)- and pre-TCR- mediated signaling, both in mature T-cells and during their development (PubMed:23514740, PubMed:25907557). Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules. |
| Cellular Location | Cell membrane; Single-pass type III membrane protein. Note=Present in lipid rafts |
| Tissue Location | Expressed in thymus, T-cells, NK cells, mast cells and, at lower levels, in spleen. Present in T-cells but not B-cells (at protein level). |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 149.00
$ 499.00
Cat# AGI1868
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