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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-MCM5 Rabbit Monoclonal Antibody
KD-Validated Anti-MCM5 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | P33992 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB4965 |
| Calculated MW | Predicted, 82 kDa, observed, 82 kDa |
| Gene Name | MCM5 |
| Aliases | MCM5; Minichromosome Maintenance Complex Component 5; CDC46; DNA Replication Licensing Factor MCM5; CDC46 Homolog; P1-CDC46; MCM5 Minichromosome MaintenanceDeficient 5, Cell Division Cycle 46 (S. Cerevisiae); Minichromosome Maintenance Deficient (S. Cerevisiae) 5 (Cell Division Cycle 46); MCM5 Minichromosome Maintenance Deficient 5, Cell Division Cycle 46; Minichromosome Maintenance Deficient 5 (Cell Division Cycle 46); EC 3.6.4.12; MGORS8 |
| Immunogen | A synthesized peptide derived from human MCM5 |
| Gene ID | 4174 |
|---|---|
| Other Names | DNA replication licensing factor MCM5 {ECO:0000303|Ref.3}, 3.6.4.12, CDC46 homolog, P1-CDC46, MCM5, CDC46 |
| Name | MCM5 |
|---|---|
| Synonyms | CDC46 |
| Function | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:16899510, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). The active ATPase sites in the MCM2- 7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). |
| Cellular Location | Nucleus. Chromosome. Note=Associated with chromatin before the formation of nuclei and detaches from it as DNA replication progresses. |
Research Areas
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Application Protocols
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$ 149.00
$ 499.00
Cat# AGI1871
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