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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-Ring Finger Protein 2 Rabbit Monoclonal Antibody
KD-Validated Anti-Ring Finger Protein 2 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC |
|---|---|
| Primary Accession | Q99496 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB5455 |
| Calculated MW | Predicted, 38 kDa, observed, 38 kDa |
| Gene Name | RNF2 |
| Aliases | RNF2; Ring Finger Protein 2; RING1B; HIPI3; BAP1; DING; BAP-1; RING2; Huntingtin-Interacting Protein 2-Interacting Protein 3; RING-Type E3 Ubiquitin Transferase RING2; E3 Ubiquitin-Protein Ligase RING2; HIP2-Interacting Protein 3; RING Finger Protein BAP-1; RING Finger Protein 1B; Protein DinG; RING Finger Protein; EC 2.3.2.27; EC 6.3.2; LUSYAM; RING1b |
| Immunogen | A synthesized peptide derived from human RING2 / RING1B / RNF2 |
| Gene ID | 6045 |
|---|---|
| Other Names | E3 ubiquitin-protein ligase RING2, 2.3.2.27, Huntingtin-interacting protein 2-interacting protein 3, HIP2-interacting protein 3, Protein DinG, RING finger protein 1B, RING1b, RING finger protein 2, RING finger protein BAP-1, RING-type E3 ubiquitin transferase RING2, RNF2, BAP1, DING, HIPI3, RING1B |
| Name | RNF2 |
|---|---|
| Synonyms | BAP1, DING, HIPI3, RING1B |
| Function | E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation (PubMed:15386022, PubMed:16359901, PubMed:21772249, PubMed:25355358, PubMed:25519132, PubMed:26151332, PubMed:33864376). H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation (By similarity). Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:16359901, PubMed:26151332). PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility (PubMed:26151332). E3 ubiquitin-protein ligase activity is enhanced by BMI1/PCGF4 (PubMed:21772249). Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1 complex, while RING1 may rather act as a modulator of RNF2/RING2 activity (Probable). Association with the chromosomal DNA is cell-cycle dependent. In resting B- and T-lymphocytes, interaction with AURKB leads to block its activity, thereby maintaining transcription in resting lymphocytes (By similarity). Also acts as a negative regulator of autophagy by mediating ubiquitination of AMBRA1, leading to its subsequent degradation (By similarity). |
| Cellular Location | Nucleus. Cytoplasm {ECO:0000250|UniProtKB:Q9CQJ4}. Chromosome {ECO:0000250|UniProtKB:Q9CQJ4}. Note=Enriched on inactive X chromosome (Xi) in female trophoblast stem (TS) cells as well as differentiating embryonic stem (ES) cells. The enrichment on Xi is transient during TS and ES cell differentiation. The association with Xi is mitotically stable in non-differentiated TS cells. Co-localizes with SAMD7 in nuclear polycomb bodies. {ECO:0000250|UniProtKB:Q9CQJ4} |
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$ 149.00
$ 499.00
Cat# AGI1891
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