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> home > Products > Primary Antibodies > Antibody Collections > Lung positive > KD-Validated Anti-Leukotriene A4 Hydrolase Mouse Monoclonal Antibody
KD-Validated Anti-Leukotriene A4 Hydrolase Mouse Monoclonal Antibody
Mouse monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC |
|---|---|
| Primary Accession | P09960 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse IgG2b |
| Clone Names | 24GB5540 |
| Calculated MW | Predicted, 69 kDa, observed, 69 kDa |
| Gene Name | LTA4H |
| Aliases | Leukotriene A4 Hydrolase; Tripeptide Aminopeptidase LTA4H; Leukotriene A-4 Hydrolase; LTA-4 Hydrolase; Testicular Secretory Protein Li 27; Leukotriene A(4) Hydrolase; EC 3.4.11.4; EC 3.3.2.6; LTA4 |
| Immunogen | Recombinant protein of human LTA4H |
| Gene ID | 4048 |
|---|---|
| Other Names | Leukotriene A-4 hydrolase, LTA-4 hydrolase, 3.3.2.6, Leukotriene A(4) hydrolase, Tripeptide aminopeptidase LTA4H, 3.4.11.4, LTA4H, LTA4 |
| Name | LTA4H |
|---|---|
| Synonyms | LTA4 |
| Function | Bifunctional zinc metalloenzyme that comprises both epoxide hydrolase (EH) and aminopeptidase activities. Acts as an epoxide hydrolase to catalyze the conversion of LTA4 to the pro-inflammatory mediator leukotriene B4 (LTB4) (PubMed:11917124, PubMed:12207002, PubMed:15078870, PubMed:18804029, PubMed:1897988, PubMed:1975494, PubMed:2244921). Also has aminopeptidase activity, with high affinity for N-terminal arginines of various synthetic tripeptides (PubMed:18804029, PubMed:20813919). In addition to its pro-inflammatory EH activity, may also counteract inflammation by its aminopeptidase activity, which inactivates by cleavage another neutrophil attractant, the tripeptide Pro-Gly-Pro (PGP), a bioactive fragment of collagen generated by the action of matrix metalloproteinase-9 (MMP9) and prolylendopeptidase (PREPL) (PubMed:20813919, PubMed:24591641). Involved also in the biosynthesis of resolvin E1 and 18S-resolvin E1 from eicosapentaenoic acid, two lipid mediators that show potent anti- inflammatory and pro-resolving actions (PubMed:21206090). |
| Cellular Location | Cytoplasm. |
| Tissue Location | Isoform 1 and isoform 2 are expressed in monocytes, lymphocytes, neutrophils, reticulocytes, platelets and fibroblasts |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI1898
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