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> home > Products > Primary Antibodies > Antibody Collections > Endometrium positive > KD-Validated Anti-AKR1A1 Mouse Monoclonal Antibody
KD-Validated Anti-AKR1A1 Mouse Monoclonal Antibody
Mouse monoclonal antibody
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- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | P14550 |
| Reactivity | Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse IgG2b |
| Clone Names | 24GB6220 |
| Calculated MW | Predicted, 37 kDa, observed, 37 kDa |
| Gene Name | AKR1A1 |
| Aliases | AKR1A1; Aldo-Keto Reductase Family 1 Member A1; ALR; Aldehyde Reductase; DD3; Dihydrodiol Dehydrogenase 3; Glucuronolactone Reductase; Glucuronate Reductase; EC 1.1.1.2; ALDR1; Aldo-Keto Reductase Family 1, Member A1 (Aldehyde Reductase); Epididymis Secretory Sperm Binding Protein Li 165mP; Epididymis Secretory Protein Li 6; Alcohol Dehydrogenase [NADP(+)]; Alcohol Dehydrogenase; EC 1.1.1.372; HEL-S-165mP; EC 1.1.1.54; EC 1.1.1.19; EC 1.1.1.20; EC 1.1.1; HEL-S-6; ARM |
| Immunogen | Recombinant protein of human AKR1A1 |
| Gene ID | 10327 |
|---|---|
| Other Names | Aldo-keto reductase family 1 member A1, 1.1.1.2, 1.1.1.372, 1.1.1.54, Alcohol dehydrogenase [NADP(+)], Aldehyde reductase, Glucuronate reductase, 1.1.1.19, S-nitroso-CoA reductase, ScorR, 1.6.-.-, AKR1A1, ALDR1, ALR |
| Name | AKR1A1 |
|---|---|
| Synonyms | ALDR1, ALR |
| Function | Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols (PubMed:10510318, PubMed:30538128). Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids, with a preference for negatively charged substrates, such as glucuronate and succinic semialdehyde (PubMed:10510318, PubMed:30538128). Functions as a detoxifiying enzyme by reducing a range of toxic aldehydes (By similarity). Reduces methylglyoxal and 3-deoxyglucosone, which are present at elevated levels under hyperglycemic conditions and are cytotoxic (By similarity). Involved also in the detoxification of lipid-derived aldehydes like acrolein (By similarity). Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN) (PubMed:11306097, PubMed:18276838). Also acts as an inhibitor of protein S-nitrosylation by mediating degradation of S-nitroso-coenzyme A (S-nitroso-CoA), a cofactor required to S- nitrosylate proteins (PubMed:30538128). S-nitroso-CoA reductase activity is involved in reprogramming intermediary metabolism in renal proximal tubules, notably by inhibiting protein S-nitrosylation of isoform 2 of PKM (PKM2) (By similarity). Also acts as a S-nitroso- glutathione reductase by catalyzing the NADPH-dependent reduction of S- nitrosoglutathione (PubMed:31649033). Displays no reductase activity towards retinoids (By similarity). |
| Cellular Location | Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9JII6}. Apical cell membrane {ECO:0000250|UniProtKB:Q9JII6} |
| Tissue Location | Widely expressed. Highly expressed in kidney, salivary gland and liver. Detected in trachea, stomach, brain, lung, prostate, placenta, mammary gland, small intestine and lung |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI1927
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