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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-OTUB1 Mouse Monoclonal Antibody
KD-Validated Anti-OTUB1 Mouse Monoclonal Antibody
Mouse monoclonal antibody
- SPECIFICATION
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- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q96FW1 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Isotype | Mouse IgG1 |
| Clone Names | 24GB6500 |
| Calculated MW | Predicted, 31 kDa, observed, 35 kDa |
| Gene Name | OTUB1 |
| Aliases | OTUB1; OTU Deubiquitinase, Ubiquitin Aldehyde Binding 1; OTU Domain-Containing Ubiquitin Aldehyde-Binding Protein 1; Ubiquitin-Specific-Processing Protease OTUB1; OTU Domain, Ubiquitin Aldehyde Binding 1; Deubiquitinating Enzyme OTUB1; Ubiquitin Thioesterase OTUB1; Otubain-1; FLJ20113; FLJ40710; OTB1; OTU1; Ubiquitin-Specific Protease Otubain 1; OTU-Domain Ubal-Binding 1; EC 3.4.19.12; EC 3.1.2; HSPC263; HOTU1 |
| Immunogen | Recombinant protein of human OTUB1 |
| Gene ID | 55611 |
|---|---|
| Other Names | Ubiquitin thioesterase OTUB1, 3.4.19.12, Deubiquitinating enzyme OTUB1, OTU domain-containing ubiquitin aldehyde-binding protein 1, Otubain-1, hOTU1, Ubiquitin-specific-processing protease OTUB1, OTUB1, OTB1, OTU1 |
| Name | OTUB1 |
|---|---|
| Synonyms | OTB1, OTU1 |
| Function | Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation (PubMed:12401499, PubMed:12704427, PubMed:14661020, PubMed:23827681). Regulator of T-cell anergy, a phenomenon that occurs when T-cells are rendered unresponsive to antigen rechallenge and no longer respond to their cognate antigen (PubMed:14661020). Acts via its interaction with RNF128/GRAIL, a crucial inductor of CD4 T-cell anergy (PubMed:14661020). Isoform 1 destabilizes RNF128, leading to prevent anergy (PubMed:14661020). In contrast, isoform 2 stabilizes RNF128 and promotes anergy (PubMed:14661020). Surprisingly, it regulates RNF128- mediated ubiquitination, but does not deubiquitinate polyubiquitinated RNF128 (PubMed:14661020). Deubiquitinates estrogen receptor alpha (ESR1) (PubMed:19383985). Mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains, but not 'Lys-63'-linked polyubiquitin chains (PubMed:18954305, PubMed:19211026, PubMed:23827681). Not able to cleave di-ubiquitin (PubMed:18954305, PubMed:23827681). Also capable of removing NEDD8 from NEDD8 conjugates, but with a much lower preference compared to 'Lys-48'-linked ubiquitin (PubMed:18954305, PubMed:23827681). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:B2RYG6}. |
| Tissue Location | Isoform 1 is ubiquitous. Isoform 2 is expressed only in lymphoid tissues such as tonsils, lymph nodes and spleen, as well as peripheral blood mononuclear cells |
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$ 399.20
$ 149.00
Cat# AGI1942
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