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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-SERPINB1 Mouse Monoclonal Antibody
KD-Validated Anti-SERPINB1 Mouse Monoclonal Antibody
Mouse monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | P30740 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Isotype | Mouse IgG1 |
| Clone Names | 24GB6545 |
| Calculated MW | Predicted, 43 kDa, observed, 40 kDa |
| Gene Name | SERPINB1 |
| Aliases | SERPINB1; Serpin Family B Member 1; MNEI; PI2; LEI; EI; Leukocyte Elastase Inhibitor; ELANH2; Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 1; Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 1; Monocyte/Neutrophil Elastase Inhibitor; Peptidase Inhibitor; M/NEI; PI-2; Protease Inhibitor 2 (Anti-Elastase), Monocyte/Neutrophil Derived; Epididymis Secretory Protein Li 27; Epididymis Luminal Protein 57; Anti-Elastase; Serpin B1; HEL-S-27; HEL57 |
| Immunogen | Recombinant protein of human SERPINB1 |
| Gene ID | 1992 |
|---|---|
| Other Names | Leukocyte elastase inhibitor, LEI, Monocyte/neutrophil elastase inhibitor, EI, M/NEI, Peptidase inhibitor 2, PI-2, Serpin B1, SERPINB1, ELANH2, MNEI, PI2 |
| Name | SERPINB1 |
|---|---|
| Synonyms | ELANH2, MNEI, PI2 |
| Function | Neutrophil serine protease inhibitor that plays an essential role in the regulation of the innate immune response, inflammation and cellular homeostasis (PubMed:30692621). Acts primarily to protect the cell from proteases released in the cytoplasm during stress or infection. These proteases are important in killing microbes but when released from granules, these potent enzymes also destroy host proteins and contribute to mortality. Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3 (PubMed:11747453, PubMed:30692621). Also acts as a potent intracellular inhibitor of GZMH by directly blocking its proteolytic activity (PubMed:23269243). During inflammation, limits the activity of inflammatory caspases CASP1, CASP4 and CASP5 by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation (PubMed:30692621). When secreted, promotes the proliferation of beta-cells via its protease inhibitory function (PubMed:26701651). |
| Cellular Location | Secreted. Cytoplasm. Cytolytic granule. Early endosome |
| Tissue Location | In human bone marrow, present in all CD45+ populations. Expression levels are highest in the neutrophil lineage, intermediate in monocytic, and lowest in lymphocytic lineage. Within the neutrophil lineage, expression is highest in promyelocytes |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI1945
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