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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-CHCHD3 Mouse Monoclonal Antibody
KD-Validated Anti-CHCHD3 Mouse Monoclonal Antibody
Mouse monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q9NX63 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse IgG1 |
| Clone Names | 24GB6565 |
| Calculated MW | Predicted, 26 kDa, observed, 26 kDa |
| Gene Name | CHCHD3 |
| Aliases | CHCHD3; Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 3; MINOS3; PPP1R22; MICOS19; Mic19; Mitochondrial Contact Site And Cristae Organizing System Subunit 19; Mitochondrial Inner Membrane Organizing System 3; Protein Phosphatase 1, Regulatory Subunit 22; MICOS Complex Subunit MIC19; FLJ20420; Coiled-Coil-Helix-Coiled-Coil-Helix Domain-Containing Protein 3, Mitochondrial; Coiled-Coil-Helix-Coiled-Coil-Helix Domain-Containing Protein 3; MIC19 |
| Immunogen | Recombinant protein of human CHCHD3 |
| Gene ID | 54927 |
|---|---|
| Other Names | MICOS complex subunit MIC19, Coiled-coil-helix-coiled-coil-helix domain-containing protein 3, CHCHD3, MIC19, MINOS3 |
| Name | CHCHD3 |
|---|---|
| Synonyms | MIC19, MINOS3 |
| Function | Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane (PubMed:25781180, PubMed:32567732, PubMed:33130824). Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:25781180, PubMed:32567732, PubMed:33130824). Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription (PubMed:22567091). |
| Cellular Location | Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q9CRB9}; Lipid-anchor; Intermembrane side {ECO:0000250|UniProtKB:Q9CRB9}. Cytoplasm. Nucleus Mitochondrion |
| Tissue Location | Detected at low levels in brain, placenta, lung, liver, kidney and pancreas with increased levels in heart and skeletal muscle. Higher expression in primary lung cancers than in normal lung tissue. |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI1947
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