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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-ATIC Mouse Monoclonal Antibody
KD-Validated Anti-ATIC Mouse Monoclonal Antibody
Mouse monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC |
|---|---|
| Primary Accession | P31939 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse IgG1 |
| Clone Names | 24GB6745 |
| Calculated MW | Predicted, 65 kDa, observed, 65 kDa |
| Gene Name | ATIC |
| Aliases | ATIC; 5-Aminoimidazole-4-Carboxamide Ribonucleotide Formyltransferase/IMP Cyclohydrolase; PURH; IMPCHASE; AICARFT; Phosphoribosylaminoimidazolecarboxamide Formyltransferase/IMP Cyclohydrolase; AICAR Transformylase/Inosine Monophosphate Cyclohydrolase; Bifunctional Purine Biosynthesis Protein ATIC; 5-Aminoimidazole-4-Carboxamide-1-Beta-D-Ribonucleotide Transformylase/Inosinicase; AICAR Formyltransferase/IMP Cyclohydrolase Bifunctional Enzyme; Epididymis Secretory Sperm Binding Protein Li 70p; Bifunctional Purine Biosynthesis Protein PURH; AICARFT/IMPCHASE; HEL-S-70p; AICAR |
| Immunogen | Recombinant protein of human ATIC |
| Gene ID | 471 |
|---|---|
| Other Names | Bifunctional purine biosynthesis protein ATIC, AICAR transformylase/inosine monophosphate cyclohydrolase, ATIC, Phosphoribosylaminoimidazolecarboxamide formyltransferase, 2.1.2.3, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase, AICAR formyltransferase, AICAR transformylase, Inosine 5'-monophosphate cyclohydrolase, IMP cyclohydrolase, 3.5.4.10, IMP synthase, Inosinicase, Bifunctional purine biosynthesis protein ATIC, N-terminally processed, ATIC (HGNC:794) |
| Name | ATIC (HGNC:794) |
|---|---|
| Function | Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis (PubMed:11948179, PubMed:14756554). Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR) (PubMed:10985775, PubMed:11948179, PubMed:9378707). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction (PubMed:10985775). Also catalyzes the cyclization of FAICAR to inosine monophosphate (IMP) (PubMed:11948179, PubMed:14756554). Is able to convert thio-AICAR to 6-mercaptopurine ribonucleotide, an inhibitor of purine biosynthesis used in the treatment of human leukemias (PubMed:10985775). Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (PubMed:25687571). |
| Cellular Location | Cytoplasm, cytosol {ECO:0000250|UniProtKB:P54113} |
| Tissue Location | Present in the heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas. |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI1969
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