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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-AKR1B1 Mouse Monoclonal Antibody
KD-Validated Anti-AKR1B1 Mouse Monoclonal Antibody
Mouse monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P15121 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse IgG1 |
| Clone Names | 24GB6775 |
| Calculated MW | Predicted, 36 kDa, observed, 36 kDa |
| Gene Name | AKR1B1 |
| Aliases | AKR1B1; Aldo-Keto Reductase Family 1 Member B; AR; Aldose Reductase; ALDR1; Aldo-Keto Reductase Family 1 Member B1; EC 1.1.1.21; ALR2; Aldo-Keto Reductase Family 1, Member B1 (Aldose Reductase); Lii5-2 CTCL Tumor Antigen; Low Km Aldose Reductase; Aldehyde Reductase 1; Aldehyde Reductase; EC 1.1.1.300; EC 1.1.1.372; EC 1.1.1.54; EC 1.1.1; ADR |
| Immunogen | Recombinant protein of human AKR1B1 |
| Gene ID | 231 |
|---|---|
| Other Names | Aldo-keto reductase family 1 member B1, 1.1.1.21, 1.1.1.300, 1.1.1.372, 1.1.1.54, Aldehyde reductase, Aldose reductase, AR, AKR1B1, ALDR1, ALR2 {ECO:0000303|PubMed:17368668} |
| Name | AKR1B1 |
|---|---|
| Synonyms | ALDR1, ALR2 {ECO:0000303|PubMed:17368668 |
| Function | Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia (PubMed:1936586). Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis- retinal (PubMed:12732097, PubMed:19010934, PubMed:8343525). Catalyzes the reduction of diverse phospholipid aldehydes such as 1-palmitoyl-2- (5-oxovaleroyl)-sn -glycero-3-phosphoethanolamin (POVPC) and related phospholipid aldehydes that are generated from the oxydation of phosphotidylcholine and phosphatdyleethanolamides (PubMed:17381426). Plays a role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS- carbonyls) (PubMed:21329684). |
| Cellular Location | Cytoplasm. |
| Tissue Location | Highly expressed in embryonic epithelial cells (EUE) in response to osmotic stress. |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI1973
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