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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-G-rich RNA sequence binding factor 1 Rabbit Monoclonal Antibody
KD-Validated Anti-G-rich RNA sequence binding factor 1 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | Q12849 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB 1890 |
| Calculated MW | Predicted, 53 kDa , observed, 53 kDa |
| Gene Name | GRSF1 |
| Aliases | GRSF1; G-Rich RNA Sequence Binding Factor 1; G-Rich Sequence Factor 1; GRSF-1 |
| Immunogen | A synthesized peptide derived from human GRSF1 |
| Gene ID | 2926 |
|---|---|
| Other Names | G-rich sequence factor 1, GRSF-1, GRSF1 |
| Name | GRSF1 |
|---|---|
| Function | Regulator of post-transcriptional mitochondrial gene expression, required for assembly of the mitochondrial ribosome and for recruitment of mRNA and lncRNA. Binds RNAs containing the 14 base G- rich element. Preferentially binds RNAs transcribed from three contiguous genes on the light strand of mtDNA, the ND6 mRNA, and the long non-coding RNAs for MT-CYB and MT-ND5, each of which contains multiple consensus binding sequences (PubMed:23473033, PubMed:23473034, PubMed:29967381). Involved in the degradosome-mediated decay of non- coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules (PubMed:29967381). Acts by unwinding G-quadruplex RNA structures in MT- ncRNA, thus facilitating their degradation by the degradosome (PubMed:29967381). G-quadruplexes (G4) are non-canonical 4 stranded structures formed by transcripts from the light strand of mtDNA (PubMed:29967381). |
| Cellular Location | [Isoform 1]: Mitochondrion matrix Note=Localizes to mitochondrial RNA granules found in close proximity to the mitochondrial nucleoids. |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI1978
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