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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-AXL Rabbit Monoclonal Antibody
KD-Validated Anti-AXL Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, ICC |
|---|---|
| Primary Accession | P30530 |
| Reactivity | Rat, Human |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB6870 |
| Calculated MW | Predicted, 98 kDa, observed, 138 kDa |
| Gene Name | AXL |
| Aliases | AXL; AXL Receptor Tyrosine Kinase; UFO; JTK11; Tyro7; ARK; Tyrosine-Protein Kinase Receptor UFO; AXL Oncogene; EC 2.7.10.1; AXL Transforming Sequence/Gene; EC 2.7.10; AXL3 |
| Immunogen | Recombinant protein of human Axl |
| Gene ID | 558 |
|---|---|
| Other Names | Tyrosine-protein kinase receptor UFO, 2.7.10.1, AXL oncogene, AXL, UFO |
| Name | AXL |
|---|---|
| Synonyms | UFO |
| Function | Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, AXL binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response. |
| Cellular Location | Cell membrane; Single-pass type I membrane protein |
| Tissue Location | Highly expressed in metastatic colon tumors. Expressed in primary colon tumors. Weakly expressed in normal colon tissue. |
Research Areas
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Application Protocols
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$ 149.00
$ 499.00
Cat# AGI1979
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