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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-BCR Rabbit Monoclonal Antibody
KD-Validated Anti-BCR Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | P11274 |
| Reactivity | Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB6945 |
| Calculated MW | Predicted, 143 kDa, observed, 160 kDa |
| Gene Name | BCR |
| Aliases | BCR; BCR Activator Of RhoGEF And GTPase; D22S662; D22S11; BCR1; CML; PHL; ALL; BCR, RhoGEF And GTPase Activating Protein; Breakpoint Cluster Region Protein; Renal Carcinoma Antigen NY-REN-26; Breakpoint Cluster Region; EC 2.7.11.1; BCR/FGFR1 Chimera Protein; FGFR1/BCR Chimera Protein |
| Immunogen | A synthesized peptide derived from human Bcr |
| Gene ID | 613 |
|---|---|
| Other Names | Breakpoint cluster region protein, 2.7.11.1, Renal carcinoma antigen NY-REN-26, BCR (HGNC:1014), BCR1, D22S11 |
| Name | BCR (HGNC:1014) |
|---|---|
| Synonyms | BCR1, D22S11 |
| Function | Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein (GAP) domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form (PubMed:17116687, PubMed:1903516, PubMed:7479768). The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form (PubMed:23940119, PubMed:7479768). The amino terminus contains an intrinsic kinase activity (PubMed:1657398). Functions as an important negative regulator of neuronal RAC1 activity (By similarity). Regulates macrophage functions such as CSF1-directed motility and phagocytosis through the modulation of RAC1 activity (PubMed:17116687). Plays a major role as a RHOA GEF in keratinocytes being involved in focal adhesion formation and keratinocyte differentiation (PubMed:23940119). |
| Cellular Location | Postsynaptic density {ECO:0000250|UniProtKB:Q6PAJ1}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q6PAJ1}. Cell projection, axon {ECO:0000250|UniProtKB:Q6PAJ1}. Synapse {ECO:0000250|UniProtKB:F1LXF1} |
Research Areas
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Application Protocols
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$ 149.00
$ 499.00
Cat# AGI1983
Ordering Information
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