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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-Clathrin Heavy Chain Rabbit Monoclonal Antibody
KD-Validated Anti-Clathrin Heavy Chain Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | Q00610 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB6960 |
| Calculated MW | Predicted, 192 kDa, observed, 192 kDa |
| Gene Name | CLTC |
| Aliases | CLTC; Clathrin Heavy Chain; CLTCL; Hc; Clathrin Heavy Chain On Chromosome 17; Clathrin, Heavy Polypeptide-Like 2; Clathrin, Heavy Polypeptide (Hc); Clathrin Heavy Chain 1; CLH-17; Clathrin, Heavy Chain (Hc); Clathrin, Heavy Chain; KIAA0034; CHC17; MRD56; CLH17; CHC |
| Immunogen | A synthesized peptide derived from human Clathrin heavy chain |
| Gene ID | 1213 |
|---|---|
| Other Names | Clathrin heavy chain 1, Clathrin heavy chain on chromosome 17, CLH-17, CLH1 |
| Name | CLH1 |
|---|---|
| Function | Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans- Golgi network. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:16968737, PubMed:21297582). The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Plays a role in early autophagosome formation (PubMed:20639872). Interaction with DNAJC6 mediates the recruitment of HSPA8 to the clathrin lattice and creates local destabilization of the lattice promoting uncoating (By similarity). |
| Cellular Location | Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Melanosome. Cytoplasm, cytoskeleton, spindle. Note=Cytoplasmic face of coated pits and vesicles. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. In complex with TACC3 and CKAP5 (forming the TACC3/ch-TOG/clathrin complex) localized to inter-microtubule bridges in mitotic spindles. |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI1984
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