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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-CINP Mouse Monoclonal Antibody
KD-Validated Anti-CINP Mouse Monoclonal Antibody
Mouse monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC |
|---|---|
| Primary Accession | Q9BW66 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Isotype | Mouse IgG2b |
| Clone Names | 24GB8100 |
| Calculated MW | Predicted, 24 kDa, observed, 27 kDa |
| Gene Name | CINP |
| Aliases | CINP; Cyclin Dependent Kinase 2 Interacting Protein; Cyclin-Dependent Kinase 2-Interacting Protein; CDK2-Interacting Protein; MGC849 |
| Immunogen | Recombinant protein of human CINP |
| Gene ID | 51550 |
|---|---|
| Other Names | Cyclin-dependent kinase 2-interacting protein, CDK2-interacting protein, CINP {ECO:0000303|PubMed:19889979, ECO:0000312|HGNC:HGNC:23789} |
| Name | CINP {ECO:0000303|PubMed:19889979, ECO:0000312|HGNC:HGNC:23789} |
|---|---|
| Function | Component of the DNA replication complex, which interacts with two kinases, CDK2 and CDC7, thereby providing a functional and physical link between CDK2 and CDC7 during firing of the origins of replication (PubMed:16082200, PubMed:19889979). Regulates ATR-mediated checkpoint signaling in response to DNA damage (PubMed:16082200, PubMed:19889979). Part of the 55LCC heterohexameric ATPase complex which is chromatin-associated and promotes replisome proteostasis to maintain replication fork progression and genome stability. Required for replication fork progression, sister chromatid cohesion, and chromosome stability. The ATPase activity is specifically enhanced by replication fork DNA and is coupled to cysteine protease-dependent cleavage of replisome substrates in response to replication fork damage. Uses ATPase activity to process replisome substrates in S- phase, facilitating their proteolytic turnover from chromatin to ensure DNA replication and mitotic fidelity (PubMed:38554706). As part of 55LCC complex, also involved in the cytoplasmic maturation steps of pre-60S ribosomal particles by promoting the release of shuttling protein RSL24D1/RLP24 from the pre-ribosomal particles (PubMed:35354024). |
| Cellular Location | Nucleus. Note=Binds to nuclear under G1 conditions, and dissociates from chromatin with the start of DNA replication. |
Research Areas
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Application Protocols
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$ 149.00
$ 499.00
Cat# AGI2021
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