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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-EIF4E2 Mouse Monoclonal Antibody
KD-Validated Anti-EIF4E2 Mouse Monoclonal Antibody
Mouse monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC |
|---|---|
| Primary Accession | O60573 |
| Reactivity | Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse IgG1 |
| Clone Names | 24GB8140 |
| Calculated MW | Predicted, 28 kDa, observed, 28 kDa |
| Gene Name | EIF4E2 |
| Aliases | EIF4E2; Eukaryotic Translation Initiation Factor 4E Family Member 2; Eukaryotic Translation Initiation Factor 4E-Like 3; EIF4EL3; IF4e; 4EHP; Eukaryotic Translation Initiation Factor 4E Homologous Protein; Eukaryotic Translation Initiation Factor 4E Type 2; MRNA Cap-Binding Protein Type 3; EIF4E-Like Protein 4E-LP; EIF-4E Type 2; H4EHP; EIF4E-Like Cap-Binding Protein; MRNA Cap-Binding Protein 4EHP; EIF4E Type 2; 4E-LP |
| Immunogen | Recombinant protein of human EIF4E2 |
| Gene ID | 9470 |
|---|---|
| Other Names | Eukaryotic translation initiation factor 4E type 2, eIF-4E type 2, eIF4E type 2, Eukaryotic translation initiation factor 4E homologous protein, Eukaryotic translation initiation factor 4E-like 3, eIF4E-like protein 4E-LP, mRNA cap-binding protein 4EHP, h4EHP, mRNA cap-binding protein type 3, EIF4E2 {ECO:0000303|PubMed:15153109, ECO:0000312|HGNC:HGNC:3293} |
| Name | EIF4E2 {ECO:0000303|PubMed:15153109, ECO:0000312|HGNC:HGNC:3293} |
|---|---|
| Function | Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation. Acts as a repressor of translation initiation (PubMed:17368478, PubMed:22751931, PubMed:25624349, PubMed:33581076, PubMed:9582349). In contrast to EIF4E, it is unable to bind eIF4G (EIF4G1, EIF4G2 or EIF4G3), suggesting that it acts by competing with EIF4E and block assembly of eIF4F at the cap (By similarity). In P-bodies, component of a complex that promotes miRNA-mediated translational repression (PubMed:28487484). Involved in virus-induced host response by mediating miRNA MIR34A-induced translational silencing which controls IFNB1 production by a negative feedback mechanism (PubMed:28487484, PubMed:33581076). |
| Cellular Location | Cytoplasm. Cytoplasm, P-body |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI2027
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