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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-DPP8 Mouse Monoclonal Antibody
KD-Validated Anti-DPP8 Mouse Monoclonal Antibody
Mouse monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q6V1X1 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse IgG1 |
| Clone Names | 24GB8195 |
| Calculated MW | Predicted, 103 kDa, observed, 103 kDa |
| Gene Name | DPP8 |
| Aliases | DPP8; Dipeptidyl Peptidase 8; DPRP1; DP8; Dipeptidyl Peptidase VIII; Prolyl Dipeptidase DPP8; MSTP141; Dipeptidyl Peptidase IV-Related Protein 1; FLJ14920; FLJ20283; MGC26191; DPP VIII; DPRP-1; Dipeptidyl Peptidase IV-Related Protein-1; Dipeptidyl-Peptidase 8; Dipeptidylpeptidase 8; EC 3.4.14.5; MSTP097; MSTP135; MST097 |
| Immunogen | Recombinant protein of human DPP8 |
| Gene ID | 54878 |
|---|---|
| Other Names | Dipeptidyl peptidase 8, DP8, 3.4.14.5, Dipeptidyl peptidase IV-related protein 1, DPRP-1, Dipeptidyl peptidase VIII, DPP VIII, Prolyl dipeptidase DPP8, DPP8 {ECO:0000303|PubMed:11012666, ECO:0000312|HGNC:HGNC:16490} |
| Name | DPP8 {ECO:0000303|PubMed:11012666, ECO:0000312|HGNC:HGNC:16490} |
|---|---|
| Function | Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2 (PubMed:11012666, PubMed:12534281, PubMed:12662155, PubMed:15039077, PubMed:15664838, PubMed:20536396, PubMed:29382749). Acts as a key inhibitor of caspase-1-dependent monocyte and macrophage pyroptosis in resting cells by preventing activation of NLRP1 and CARD8 (PubMed:27820798, PubMed:29967349, PubMed:32796818). Sequesters the cleaved C-terminal part of NLRP1 and CARD8, which respectively constitute the active part of the NLRP1 and CARD8 inflammasomes, in a ternary complex, thereby preventing their oligomerization and activation (PubMed:33731929, PubMed:33731932, PubMed:34019797). The dipeptidyl peptidase activity is required to suppress NLRP1 and CARD8; however, neither NLRP1 nor CARD8 are bona fide substrates of DPP8, suggesting the existence of substrate(s) required for NLRP1 and CARD8 inhibition (By similarity). |
| Cellular Location | Cytoplasm |
| Tissue Location | Ubiquitously expressed, with highest levels in testis, placenta, prostate, muscle and brain |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI2033
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