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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-DDX50 Mouse Monoclonal Antibody
KD-Validated Anti-DDX50 Mouse Monoclonal Antibody
Mouse monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, ICC |
|---|---|
| Primary Accession | Q9BQ39 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse IgG2b |
| Clone Names | 24GB8345 |
| Calculated MW | Predicted, 83 kDa, observed, 83 kDa |
| Gene Name | DDX50 |
| Aliases | DDX50; DExD-Box Helicase 50; RH-II/GuB; GU2; GUB; DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 50; ATP-Dependent RNA Helicase DDX50; DEAD-Box Helicase 50; DEAD Box Protein 50; MGC3199; Gu-Beta; Malignant Cell Derived RNA Helicase; RNA Helicase II/Gu Beta; Nucleolar Protein GU2; Nucleolar Protein Gu2; EC 3.6.4.13; EC 3.6.1; Mcdrh |
| Immunogen | Recombinant protein of human DDX50 |
| Gene ID | 79009 |
|---|---|
| Other Names | ATP-dependent RNA helicase DDX50, 3.6.4.13, DEAD box protein 50, Gu-beta, Nucleolar protein Gu2, DDX50 |
| Name | DDX50 |
|---|---|
| Function | ATP-dependent RNA helicase that may play a role in various aspects of RNA metabolism including pre-mRNA splicing or ribosomal RNA production (PubMed:12027455). Also acts as a viral restriction factor and promotes the activation of the NF-kappa-B and IRF3 signaling pathways following its stimulation with viral RNA or infection with RNA and DNA viruses (PubMed:35215908). For instance, decreases vaccinia virus, herpes simplex virus, Zika virus or dengue virus replication during the early stage of infection (PubMed:28181036, PubMed:35215908). Mechanistically, acts via the adapter TICAM1 and independently of the DDX1-DDX21-DHX36 helicase complex to induce the production of interferon-beta (PubMed:35215908). |
| Cellular Location | Nucleus, nucleolus. Cytoplasm Note=Accumulates in the cytoplasm to activate signaling upstream of IRF3 during viral infection. |
| Tissue Location | Highest expression in skeletal muscle, liver, heart, placenta, and kidney. |
Research Areas
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Application Protocols
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$ 149.00
$ 499.00
Cat# AGI2047
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