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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-LAMP1 /CD107a Rabbit Monoclonal Antibody
KD-Validated Anti-LAMP1 /CD107a Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, ICC |
|---|---|
| Primary Accession | P11279 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB760 |
| Calculated MW | Predicted, 45 kDa , observed, 120 kDa |
| Gene Name | LAMP1 |
| Aliases | CD107a; Lysosome-Associated Membrane Glycoprotein 1; Lysosome-Associated Membrane Protein 1; CD107 Antigen-Like Family Member A; LAMP-1; Lysosomal-Associated Membrane Protein 1; CD107a Antigen; LGP120; LAMPA |
| Immunogen | A synthesized peptide derived from human LAMP1 |
| Gene ID | 3916 |
|---|---|
| Other Names | Lysosome-associated membrane glycoprotein 1, LAMP-1, Lysosome-associated membrane protein 1, CD107 antigen-like family member A, CD107a, LAMP1 {ECO:0000303|PubMed:23632890, ECO:0000312|HGNC:HGNC:6499} |
| Name | LAMP1 {ECO:0000303|PubMed:23632890, ECO:0000312|HGNC:HGNC:6499} |
|---|---|
| Function | Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, lysosomal pH regulation, autophagy and cholesterol homeostasis (PubMed:37390818). Acts as an important regulator of lysosomal lumen pH regulation by acting as a direct inhibitor of the proton channel TMEM175, facilitating lysosomal acidification for optimal hydrolase activity (PubMed:37390818). Also plays an important role in NK-cells cytotoxicity (PubMed:2022921, PubMed:23632890). Mechanistically, participates in cytotoxic granule movement to the cell surface and perforin trafficking to the lytic granule (PubMed:23632890). In addition, protects NK-cells from degranulation-associated damage induced by their own cytotoxic granule content (PubMed:23847195). Presents carbohydrate ligands to selectins (PubMed:7685349). |
| Cellular Location | Lysosome membrane; Single-pass type I membrane protein. Endosome membrane; Single- pass type I membrane protein. Late endosome membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. Cytolytic granule membrane; Single-pass type I membrane protein. Note=This protein shuttles between lysosomes, endosomes, and the plasma membrane (By similarity). Colocalizes with OSBPL1A at the late endosome (PubMed:16176980). {ECO:0000250|UniProtKB:P05300, ECO:0000269|PubMed:16176980, ECO:0000269|PubMed:17897319} |
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$ 149.00
$ 499.00
Cat# AGI2050
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