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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-DDOST Mouse Monoclonal Antibody
KD-Validated Anti-DDOST Mouse Monoclonal Antibody
Mouse monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P39656 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse IgG2a |
| Clone Names | 24GB13105 |
| Calculated MW | Predicted, 51 kDa, observed, 49 kDa |
| Gene Name | DDOST |
| Aliases | DDOST; Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase Non-Catalytic Subunit; OST48; KIAA0115; WBP1; OST; Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase 48 KDa Subunit; Advanced Glycation End-Product Receptor 1; Oligosaccharyl Transferase 48 KDa Subunit; Oligosaccharyltransferase Subunit 48; Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase Subunit (Non-Catalytic); Dolichyl-Diphosphooligosaccharide-Protein Glycosyltransferase; Dolichyl-Diphosphooligosaccharide-Protein Glycotransferase; Advanced Glycation Endproduct Receptor 1; Oligosaccharyltransferase 48 KDa Subunit; DDOST 48 KDa Subunit; EC 2.4.1.119; OKSWcl45; AGER1; CDG1R; GATD6 |
| Immunogen | Recombinant protein of human DDOST |
| Gene ID | 1650 |
|---|---|
| Other Names | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit, DDOST 48 kDa subunit, Oligosaccharyl transferase 48 kDa subunit, DDOST (HGNC:2728), KIAA0115, OST48 |
| Name | DDOST (HGNC:2728) |
|---|---|
| Synonyms | KIAA0115, OST48 |
| Function | Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (PubMed:31831667). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (By similarity). Required for the assembly of both SST3A- and SS3B-containing OST complexes (PubMed:22467853). |
| Cellular Location | Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q29381}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q29381} |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI2063
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