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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-GEMIN8 Mouse Monoclonal Antibody
KD-Validated Anti-GEMIN8 Mouse Monoclonal Antibody
Mouse monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q9NWZ8 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse IgG1 |
| Clone Names | 24GB13110 |
| Calculated MW | Predicted, 29 kDa, observed, 31 kDa |
| Gene Name | GEMIN8 |
| Aliases | GEMIN8; Gem Nuclear Organelle Associated Protein 8; FAM51A1; Family With Sequence Similarity 51, Member A1; Gem-Associated Protein 8; FLJ20514; Gemin-8; Gem (Nuclear Organelle) Associated Protein 8; Protein FAM51A1 |
| Immunogen | Recombinant protein of human GEMIN8 |
| Gene ID | 54960 |
|---|---|
| Other Names | Gem-associated protein 8, Gemin-8, Protein FAM51A1, GEMIN8, FAM51A1 |
| Name | GEMIN8 |
|---|---|
| Synonyms | FAM51A1 |
| Function | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre- mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. |
| Cellular Location | Nucleus, gem. Cytoplasm. Note=Found in nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies. Also found in the cytoplasm |
Research Areas
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Application Protocols
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$ 149.00
$ 499.00
Cat# AGI2064
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