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> home > Products > Primary Antibodies > Antibody Collections > SARS-Human interaction partners > KD-Validated Anti-NMNAT1 Mouse Monoclonal Antibody
KD-Validated Anti-NMNAT1 Mouse Monoclonal Antibody
Mouse monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q9HAN9 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Isotype | Mouse IgG1 |
| Clone Names | 24GB13215 |
| Calculated MW | Predicted, 32 kDa, observed, 32 kDa |
| Gene Name | NMNAT1 |
| Aliases | NMNAT1; Nicotinamide Nucleotide Adenylyltransferase 1; NMNAT; Nicotinamide/Nicotinic Acid Mononucleotide Adenylyltransferase 1; PNAT1; Nicotinate-Nucleotide Adenylyltransferase 1; NMN/NaMN Adenylyltransferase 1; NaMN Adenylyltransferase 1; NMN Adenylyltransferase 1; LCA9; Nicotinamide Mononucleotide Adenylyltransferase 1; Nicotinamide-Nucleotide Adenylyltransferase 1; Nicotinamide Nucleotide Adenylyltransferase; Pyridine Nucleotide Adenylyltransferase 1; Leber'S Congenital Amaurosis 9; Leber Congenital Amaurosis 9; EC 2.7.7.18; EC 2.7.7.1; SHILCA |
| Immunogen | Recombinant protein of human NMNAT1 |
| Gene ID | 64802 |
|---|---|
| Other Names | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1, NMN/NaMN adenylyltransferase 1, 2.7.7.1, 2.7.7.18, Nicotinamide-nucleotide adenylyltransferase 1, NMN adenylyltransferase 1, Nicotinate-nucleotide adenylyltransferase 1, NaMN adenylyltransferase 1, NMNAT1 (HGNC:17877), NMNAT |
| Name | NMNAT1 (HGNC:17877) |
|---|---|
| Synonyms | NMNAT |
| Function | Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP (PubMed:17402747). Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency (PubMed:17402747). Can use triazofurin monophosphate (TrMP) as substrate (PubMed:17402747). Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+) (PubMed:17402747). For the pyrophosphorolytic activity, prefers NAD(+) and NaAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less effectively (PubMed:17402747). Involved in the synthesis of ATP in the nucleus, together with PARP1, PARG and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). Also acts as a cofactor for glutamate and aspartate ADP-ribosylation by directing PARP1 catalytic activity to glutamate and aspartate residues on histones (By similarity). Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+) (PubMed:17402747). Protects against axonal degeneration following mechanical or toxic insults (By similarity). Neural protection does not correlate with cellular NAD(+) levels but may still require enzyme activity (By similarity). |
| Cellular Location | Nucleus |
| Tissue Location | Widely expressed with highest levels in skeletal muscle, heart and kidney. Also expressed in the liver pancreas and placenta. Widely expressed throughout the brain |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI2078
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