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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-IFNGR1 Rabbit Monoclonal Antibody
KD-Validated Anti-IFNGR1 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | P15260 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB13660 |
| Calculated MW | Predicted, 54 kDa, observed, 50-100 kDa |
| Gene Name | IFNGR1 |
| Aliases | IFNGR1; Interferon Gamma Receptor 1; CD119; IFN-Gamma Receptor 1; IFN-Gamma-R-Alpha; CD119 Antigen; IFN-Gamma-R1; CDw119; IFNGR; Interferon-Gamma Receptor Alpha Chain; Interferon Gamma Receptor Alpha-Chain; Immune Interferon Receptor 1; Antiviral Protein, Type 2; AVP, Type 2; IMD27A; IMD27B |
| Immunogen | A synthesized peptide derived from human IFNGR1 |
| Gene ID | 3459 |
|---|---|
| Other Names | Interferon gamma receptor 1 {ECO:0000312|HGNC:HGNC:5439}, IFN-gamma receptor 1, IFN-gamma-R1, CDw119, Interferon gamma receptor alpha-chain, IFN-gamma-R-alpha, CD119, IFNGR1 (HGNC:5439) |
| Name | IFNGR1 (HGNC:5439) |
|---|---|
| Function | Receptor subunit for interferon gamma/INFG that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation (PubMed:20015550). Associates with transmembrane accessory factor IFNGR2 to form a functional receptor (PubMed:10986460, PubMed:2971451, PubMed:7615558, PubMed:7617032, PubMed:7673114). Upon ligand binding, the intracellular domain of IFNGR1 opens out to allow association of downstream signaling components JAK1 and JAK2. In turn, activated JAK1 phosphorylates IFNGR1 to form a docking site for STAT1. Subsequent phosphorylation of STAT1 leads to dimerization, translocation to the nucleus, and stimulation of target gene transcription (PubMed:28883123). STAT3 can also be activated in a similar manner although activation seems weaker. IFNGR1 intracellular domain phosphorylation also provides a docking site for SOCS1 that regulates the JAK-STAT pathway by competing with STAT1 binding to IFNGR1 (By similarity). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 149.00
$ 499.00
Cat# AGI2104
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