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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-NPC2 Rabbit Monoclonal Antibody
KD-Validated Anti-NPC2 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | P61916 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB13695 |
| Calculated MW | Predicted, 17 kDa, observed, 17 kDa |
| Gene Name | NPC2 |
| Aliases | NPC2; NPC Intracellular Cholesterol Transporter 2; HE1; EDDM1; Niemann-Pick Disease Type C2 Protein; Human Epididymis-Specific Protein 1; Epididymal Protein 1; NP-C2; Epididymis Secretory Sperm Binding Protein; Tissue-Specific Secretory Protein; Epididymal Secretory Protein E1; Niemann-Pick Disease, Type C2; He1 |
| Immunogen | Recombinant protein of human Niemann Pick C2 |
| Gene ID | 10577 |
|---|---|
| Other Names | NPC intracellular cholesterol transporter 2 {ECO:0000312|HGNC:HGNC:14537}, Epididymal secretory protein E1, Human epididymis-specific protein 1, He1, Niemann-Pick disease type C2 protein, NPC2 (HGNC:14537), HE1 |
| Name | NPC2 (HGNC:14537) |
|---|---|
| Synonyms | HE1 |
| Function | Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment (PubMed:11125141, PubMed:15937921, PubMed:17018531, PubMed:18772377, PubMed:29580834). Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1 (PubMed:17018531, PubMed:18772377, PubMed:27238017). May bind and mobilize cholesterol that is associated with membranes (PubMed:18823126). NPC2 binds cholesterol with a 1:1 stoichiometry (PubMed:17018531). Can bind a variety of sterols, including lathosterol, desmosterol and the plant sterols stigmasterol and beta-sitosterol (PubMed:17018531). The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport (By similarity). |
| Cellular Location | Secreted. Endoplasmic reticulum. Lysosome Note=Interaction with cell-surface M6PR mediates endocytosis and targeting to lysosomes. |
| Tissue Location | Detected in gallbladder bile (PubMed:21315718). Detected in fibroblasts, kidney, liver, spleen, small intestine, placenta and testis (at protein level) (PubMed:11125141). Epididymis |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI2106
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