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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-NTH1 Rabbit Monoclonal Antibody
KD-Validated Anti-NTH1 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC |
|---|---|
| Primary Accession | P78549 |
| Reactivity | Rat, Human |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB13700 |
| Calculated MW | Predicted, 34 kDa, observed, 34 kDa |
| Gene Name | NTHL1 |
| Aliases | NTHL1; Nth Like DNA Glycosylase 1; OCTS3; NTH1; Bifunctional DNA N-Glycosylase/DNA-(Apurinic Or Apyrimidinic Site) Lyase; Endonuclease III-Like Protein 1; DNA Glycosylase/AP Lyase; HNTH1; Bifunctional DNA N-Glycoslyase/DNA-(Apurinic Or Apyrimidinic Site) Lyase; Nth Endonuclease III-Like 1 (E. Coli); Nth (E.Coli Endonuclease III)-Like 1; Nth Endonuclease III-Like 1; DNA Glycoslyase/AP Lyase; EC 4.2.99.18; EC 3.2.2.-;FAP3 |
| Immunogen | Recombinant protein of human NTH1 |
| Gene ID | 4913 |
|---|---|
| Other Names | Endonuclease III-like protein 1 {ECO:0000255|HAMAP-Rule:MF_03183}, hNTH1, 3.2.2.- {ECO:0000255|HAMAP-Rule:MF_03183, ECO:0000269|PubMed:9927729}, 4.2.99.18 {ECO:0000255|HAMAP-Rule:MF_03183, ECO:0000269|PubMed:9927729}, Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase {ECO:0000255|HAMAP-Rule:MF_03183}, DNA glycosylase/AP lyase {ECO:0000255|HAMAP-Rule:MF_03183}, NTHL1 {ECO:0000255|HAMAP-Rule:MF_03183}, NTH1, OCTS3 |
| Name | NTHL1 {ECO:0000255|HAMAP-Rule:MF_03183} |
|---|---|
| Synonyms | NTH1, OCTS3 |
| Function | Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage (PubMed:29610152, PubMed:9927729). The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta- elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. Also has 8-oxo-7,8-dihydroguanine (8-oxoG) DNA glycosylase activity. Acts preferentially on DNA damage opposite guanine residues in DNA. Is able to process lesions in nucleosomes without requiring or inducing nucleosome disruption. |
| Cellular Location | Nucleus {ECO:0000255|HAMAP-Rule:MF_03183, ECO:0000269|PubMed:10882850, ECO:0000269|PubMed:12531031, ECO:0000269|PubMed:9611236}. Mitochondrion {ECO:0000255|HAMAP- Rule:MF_03183, ECO:0000269|PubMed:9611236} |
| Tissue Location | Widely expressed with highest levels in heart and lowest levels in lung and liver. |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI2107
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