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KD-Validated Anti-UBE2T Rabbit Polyclonal Antibody

Rabbit polyclonal antibody

     
  • WB - KD-Validated Anti-UBE2T Rabbit Polyclonal Antibody AGI2139
    Western blotting analysis using anti-UBE2T antibody (Cat#AGI2139). Total cell lysates (30 µg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with anti-UBE2T antibody (Cat#AGI2139, 1:2,500) and HRP-conjugated goat anti-rabbit secondary antibody respectively.
    detail
  • WB - KD-Validated Anti-UBE2T Rabbit Polyclonal Antibody AGI2139
    Western blotting analysis using anti-UBE2T antibody (Cat #AGI2139). UBE2T expression in wild-type (WT) and UBE2T shRNA knockdown (KD) HeLa cells with 20 µg of total cell lysates. Hsp90 α serves as a loading control. The blot was incubated with anti-UBE2T antibody (Cat #AGI2139, 1:2,500) and HRP-conjugated goat anti-rabbit secondary antibody (Cat #201, 1:20,000) respectively.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q9NPD8
Reactivity Rat, Human, Mouse
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW Predicted, 23 kDa, observed, 21 kDa
Gene Name UBE2T
Aliases UBE2T; Ubiquitin Conjugating Enzyme E2 T; HSPC150; FANCT; Cell ProlifeRation-Inducing Gene 50 Protein; Ubiquitin-Conjugating Enzyme E2 T; E2 Ubiquitin-Conjugating Enzyme T; Ubiquitin Carrier Protein T; Ubiquitin-Protein Ligase T; HSPC150 Protein Similar To Ubiquitin-Conjugating Enzyme; Ubiquitin-Conjugating Enzyme E2T (Putative); Ubiquitin-Conjugating Enzyme E2T; Ubiquitin Conjugating Enzyme E2T; EC 2.3.2.23; PIG50
Immunogen A synthesized peptide derived from human UBE2T
Additional Information
Gene ID 29089
Other Names Ubiquitin-conjugating enzyme E2 T, 2.3.2.23, Cell proliferation-inducing gene 50 protein, E2 ubiquitin-conjugating enzyme T, Ubiquitin carrier protein T, Ubiquitin-protein ligase T, UBE2T
Protein Information
Name UBE2T
Function Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair. Acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway (PubMed:16916645, PubMed:17938197, PubMed:19111657, PubMed:19589784, PubMed:28437106). Also mediates monoubiquitination of FANCL and FANCI (PubMed:16916645, PubMed:17938197, PubMed:19111657, PubMed:19589784). May contribute to ubiquitination and degradation of BRCA1 (PubMed:19887602). In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11'-, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination (PubMed:20061386).
Cellular Location Nucleus. Note=Accumulates to chromatin
Research Areas
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$ 149.00
$ 499.00
Cat# AGI2139
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