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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-NAGK Mouse Monoclonal Antibody
KD-Validated Anti-NAGK Mouse Monoclonal Antibody
Mouse monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC |
|---|---|
| Primary Accession | Q9UJ70 |
| Reactivity | Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse IgG1 |
| Clone Names | 24GB14215 |
| Calculated MW | Predicted, 37 kDa, observed, 35 kDa |
| Gene Name | NAGK |
| Aliases | NAGK; N-Acetylglucosamine Kinase; GNK; N-Acetyl-D-Glucosamine Kinase; N-Acetyl-D-Mannosamine Kinase; Muramyl Dipeptide Kinase; GlcNAc Kinase; EC 2.7.1.59; Epididymis Secretory Sperm Binding Protein; EC 2.7.1.60; EC 2.7.1.-; HSA242910 |
| Immunogen | Recombinant protein of human NAGK |
| Gene ID | 55577 |
|---|---|
| Other Names | N-acetyl-D-glucosamine kinase, N-acetylglucosamine kinase, 2.7.1.59, GlcNAc kinase, Muramyl dipeptide kinase, 2.7.1.-, N-acetyl-D-mannosamine kinase, 2.7.1.60, NAGK {ECO:0000303|PubMed:36002575, ECO:0000312|HGNC:HGNC:17174} |
| Name | NAGK {ECO:0000303|PubMed:36002575, ECO:0000312|HGNC:HGNC:17174} |
|---|---|
| Function | Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate (PubMed:22692205). Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded (PubMed:22692205). Also has N-acetylmannosamine (ManNAc) kinase activity (By similarity). Also involved in innate immunity by promoting detection of bacterial peptidoglycan by NOD2: acts by catalyzing phosphorylation of muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, to generate 6-O-phospho-muramyl dipeptide, which acts as a direct ligand for NOD2 (PubMed:36002575). |
| Tissue Location | Ubiquitous.. |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI2175
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