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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-MYH9 Mouse Monoclonal Antibody
KD-Validated Anti-MYH9 Mouse Monoclonal Antibody
Mouse monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC |
|---|---|
| Primary Accession | P35579 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Isotype | Mouse IgG2b |
| Clone Names | 24GB14225 |
| Calculated MW | Predicted, 227 kDa, observed, 227 kDa |
| Gene Name | MYH9 |
| Aliases | MYH9; Myosin Heavy Chain 9; NMHC-II-A; NMMHCA; EPSTS; FTNS; MHA; Cellular Myosin Heavy Chain, Type A; Nonmuscle Myosin Heavy Chain II-A; Non-Muscle Myosin Heavy Chain IIa; Non-Muscle Myosin Heavy Chain A; MMHC-IIA; Myosin-9; DFNA17; Myosin, Heavy Polypeptide 9, Non-Muscle; Non-Muscle Myosin Heavy Polypeptide 9; Myosin Heavy Chain, Non-Muscle IIa; Myosin, Heavy Chain 9, Non-Muscle; Non-Muscle Myosin Heavy Chain 9; Nonmuscle Myosin IIA2; NMMHC II-A; NMMHC-A; BDPLT6; MATINS |
| Immunogen | Recombinant protein of human MYH9 |
| Gene ID | 4627 |
|---|---|
| Other Names | Myosin-9, Cellular myosin heavy chain, type A, Myosin heavy chain 9, Myosin heavy chain, non-muscle IIa, Non-muscle myosin heavy chain A, NMMHC-A, Non-muscle myosin heavy chain IIa, NMMHC II-a, NMMHC-IIA, MYH9 |
| Name | MYH9 |
|---|---|
| Function | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). |
| Cellular Location | Cytoplasm, cytoskeleton. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q8VDD5}. Cytoplasmic vesicle, secretory vesicle, Cortical granule {ECO:0000250|UniProtKB:Q8VDD5}. Cell membrane Note=Colocalizes with actin filaments at lamellipodia margins and at the leading edge of migrating cells (PubMed:20052411). In retinal pigment epithelial cells, predominantly localized to stress fiber-like structures with some localization to cytoplasmic puncta (PubMed:27331610). |
| Tissue Location | In the kidney, expressed in the glomeruli. Also expressed in leukocytes. |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI2177
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