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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-TRIM34 Mouse Monoclonal Antibody
KD-Validated Anti-TRIM34 Mouse Monoclonal Antibody
Mouse monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC |
|---|---|
| Primary Accession | Q9BYJ4 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Isotype | Mouse IgG2a |
| Clone Names | 24GB14230 |
| Calculated MW | Predicted, 57 kDa, observed, 51 kDa |
| Gene Name | TRIM34 |
| Aliases | TRIM34; Tripartite Motif Containing 34; RNF21; Interferon-Responsive Finger Protein 1; E3 Ubiquitin-Protein Ligase TRIM34; IFP1; Ring Finger Protein 21, Interferon-Responsive; Tripartite Motif-Containing 34; RING Finger Protein 21; EC 2.3.2.27; EC 6.3.2 |
| Immunogen | Recombinant protein of human TRIM34 |
| Gene ID | 53840 |
|---|---|
| Other Names | E3 ubiquitin-protein ligase TRIM34, 2.3.2.27, Interferon-responsive finger protein 1, RING finger protein 21, TRIM34, IFP1, RNF21 |
| Name | TRIM34 |
|---|---|
| Synonyms | IFP1, RNF21 |
| Function | Functions as antiviral protein and contributes to the defense against retroviral infections (PubMed:17156811, PubMed:32282853). Acts as a capsid-specific restriction factor with the help of TRIM5 and prevents infection from non-host-adapted retroviruses (PubMed:32282853). During influenza A virus infection, promotes programmed cell death by targeting ZBP1 for 'Lys-63'-linked polyubiquitination (PubMed:35065966). In turn, promotes ZBP1 recruitment of RIPK3 to mediate virus-induced programmed necrosis (PubMed:35065966). Negatively regulates the function of mitochondria by enhancing mitochondrial depolarization leading to cytochrome c release and mitochondria-dependent apoptosis (PubMed:31956709). Also promotes the formation of multinucleated giant cells by means of cell fusion and phagocytosis in epithelial cells (PubMed:31487507). |
| Cellular Location | Cytoplasm Mitochondrion. Note=Localizes in cytoplasmic bodies together with TRIM5 and incoming HIV-1 capsids during infection. |
| Tissue Location | [Isoform 1]: Is the most abundant form. It is highly expressed in the placenta, spleen, colon and peripheral blood leukocytes. |
Research Areas
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$ 399.20
$ 149.00
Cat# AGI2178
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