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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-CENPA Rabbit Monoclonal Antibody
KD-Validated Anti-CENPA Rabbit Monoclonal Antibody
Rabbit monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P49450 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 25GB95 |
| Calculated MW | Predicted, 16 kDa, observed, 18 kDa |
| Gene Name | CENPA |
| Aliases | CENPA; Centromere Protein A; CENP-A; Histone H3-Like Centromeric Protein A; CenH3; Centromere-Specific Histone; Centromere Protein A, 17kDa; Centromere Autoantigen A; Centromere Protein A (17kD) |
| Immunogen | A synthesized peptide derived from human CENPA |
| Gene ID | 1058 |
|---|---|
| Other Names | Histone H3-like centromeric protein A, Centromere autoantigen A, Centromere protein A, CENP-A, CENPA |
| Name | CENPA |
|---|---|
| Function | Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes (PubMed:11756469, PubMed:14667408, PubMed:15282608, PubMed:15475964, PubMed:15702419, PubMed:17651496, PubMed:19114591, PubMed:20739937, PubMed:27499292, PubMed:7962047, PubMed:9024683). Replaces conventional H3 in the nucleosome core of centromeric chromatin that serves as an assembly site for the inner kinetochore (PubMed:18072184). The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well- ordered and rigid compared to nucleosomes containing histone H3 (PubMed:26878239, PubMed:27499292). May serve as an epigenetic mark that propagates centromere identity through replication and cell division (PubMed:15282608, PubMed:15475964, PubMed:20739937, PubMed:21478274, PubMed:26878239). Required for recruitment and assembly of kinetochore proteins, and as a consequence required for progress through mitosis, chromosome segregation and cytokinesis (PubMed:11756469, PubMed:14667408, PubMed:18072184, PubMed:23818633, PubMed:25556658, PubMed:27499292). |
| Cellular Location | Nucleus. Chromosome, centromere. Note=Localizes exclusively to sites of kinetochore assembly in centromeres. Occupies a compact domain at the inner kinetochore plate stretching across 2 thirds of the length of the constriction but encompassing only one third of the constriction width and height (PubMed:19114591) Phosphorylation at Ser-68 during early mitosis abolishes association with chromatin and centromeres and results in dispersed nuclear location (PubMed:25556658). |
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$ 149.00
$ 499.00
Cat# AGI2196
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