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KD-Validated Anti-CSNK1A1 Rabbit Monoclonal Antibody
Rabbit monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC |
|---|---|
| Primary Accession | P48729 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 25GB125 |
| Calculated MW | Predicted, 39 kDa, observed, 34 kDa |
| Gene Name | CSNK1A1 |
| Aliases | CSNK1A1; Casein Kinase 1 Alpha 1; CK1; CK1a; CKIa; Casein Kinase I Isoform Alpha; Clock Regulator Kinase; EC 2.7.11.1; CKI-Alpha; CK1alpha; CKIalpha; Epididymis Secretory Sperm Binding Protein Li 77p; Down-Regulated In Lung Cancer; Casein Kinase 1, Alpha; HEL-S-77p; HLCDGP1; PRO2975 |
| Immunogen | A synthesized peptide derived from human Casein Kinase 1 alpha |
| Gene ID | 1452 |
|---|---|
| Other Names | Casein kinase I isoform alpha, CKI-alpha, 2.7.11.1, CK1, CSNK1A1 |
| Name | CSNK1A1 |
|---|---|
| Function | Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates (PubMed:11955436, PubMed:1409656, PubMed:18305108, PubMed:23902688). It can phosphorylate a large number of proteins (PubMed:11955436, PubMed:1409656, PubMed:18305108, PubMed:23902688). Participates in Wnt signaling (PubMed:11955436). Phosphorylates CTNNB1 at 'Ser-45' (PubMed:11955436). May phosphorylate PER1 and PER2 (By similarity). May play a role in segregating chromosomes during mitosis (PubMed:1409656). May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (PubMed:23902688). Acts as a positive regulator of mTORC1 and mTORC2 signaling in response to nutrients by mediating phosphorylation of DEPTOR inhibitor (PubMed:22017875, PubMed:22017877). Acts as an inhibitor of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (By similarity). |
| Cellular Location | Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Nucleus speckle. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q8BK63}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q8BK63}. Note=Localizes to the centrosome in interphase cells, and to kinetochore fibers during mitosis. Also recruited to the keratin cytoskeleton (PubMed:23902688) |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI2198
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