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> home > Products > Primary Antibodies > Antibody Collections > Skin Melanoma positive > KD-Validated Anti-COX5B Rabbit Monoclonal Antibody
KD-Validated Anti-COX5B Rabbit Monoclonal Antibody
Rabbit monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC |
|---|---|
| Primary Accession | P10606 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 25GB140 |
| Calculated MW | Predicted, 14 kDa, observed, 14 kDa |
| Gene Name | COX5B |
| Aliases | COX5B; Cytochrome C Oxidase Subunit 5B; Cytochrome C Oxidase Subunit 5B, Mitochondrial; Cytochrome C Oxidase Subunit Vb; Cytochrome C Oxidase Polypeptide VB, Mitochondrial; Epididymis Secretory Sperm Binding Protein; Cytochrome C Oxidase Polypeptide Vb; COXVB |
| Immunogen | A synthesized peptide derived from human COX5B |
| Gene ID | 1329 |
|---|---|
| Other Names | Cytochrome c oxidase subunit 5B, mitochondrial, Cytochrome c oxidase polypeptide Vb, COX5B |
| Name | COX5B |
|---|---|
| Function | Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. |
| Cellular Location | Mitochondrion inner membrane; Peripheral membrane protein; Matrix side |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 149.00
$ 499.00
Cat# AGI2200
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