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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-KDM2A Rabbit Monoclonal Antibody
KD-Validated Anti-KDM2A Rabbit Monoclonal Antibody
Rabbit monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC |
|---|---|
| Primary Accession | Q9Y2K7 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 25GB160 |
| Calculated MW | Predicted, 133 kDa, observed, 133 kDa |
| Gene Name | KDM2A |
| Aliases | KDM2A; Lysine Demethylase 2A; JHDM1A; FBL11; CXXC8; FBL7; F-Box And Leucine-Rich Repeat Protein 11; KIAA1004; LILINA; FBXL11; JmjC Domain-Containing Histone Demethylation Protein 1A; Jumonji C Domain-Containing Histone Demethylase 1A; [Histone-H3]-Lysine-36 Demethylase 1A; Lysine (K)-Specific Demethylase 2A; CXXC-Type Zinc Finger Protein 8; Lysine-Specific Demethylase 2A; F-Box/LRR-Repeat Protein 11; DKFZP434M1735; EC 1.14.11.27; FLJ00115; F-Box Protein Lilina; F-Box Protein FBL11; F-Box Protein FBL7 |
| Immunogen | A synthesized peptide derived from human FBXL11 |
| Gene ID | 22992 |
|---|---|
| Other Names | Lysine-specific demethylase 2A, 1.14.11.27, CXXC-type zinc finger protein 8, F-box and leucine-rich repeat protein 11, F-box protein FBL7, F-box protein Lilina, F-box/LRR-repeat protein 11, JmjC domain-containing histone demethylation protein 1A, [Histone-H3]-lysine-36 demethylase 1A, KDM2A |
| Name | KDM2A |
|---|---|
| Function | Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis. Regulates circadian gene expression by repressing the transcriptional activator activity of CLOCK-BMAL1 heterodimer and RORA in a catalytically- independent manner (PubMed:26037310). |
| Cellular Location | Nucleus, nucleoplasm. Chromosome Note=Punctate expression throughout the nucleoplasm and enriched in the perinucleolar region (PubMed:19001877, PubMed:20417597). Specifically nucleates at CpG islands where it's presence results in chromatin depleted in H3K36me2 (PubMed:19001877, PubMed:20417597) |
| Tissue Location | Widely expressed, with highest levels in brain, testis and ovary, followed by lung. |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI2203
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