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KD-Validated Anti-CRTC2 Rabbit Monoclonal Antibody
Rabbit monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC |
|---|---|
| Primary Accession | Q53ET0 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 25GB250 |
| Calculated MW | Predicted, 73 kDa, observed, 75-80 kDa |
| Gene Name | CRTC2 |
| Aliases | CRTC2; CREB Regulated Transcription Coactivator 2; TORC2; CREB-Regulated Transcription Coactivator 2; TORC-2; Transducer Of Regulated CAMP Response Element-Binding Protein (CREB) 2; Transducer Of Regulated CAMP Response Element-Binding Protein 2; Transducer Of CREB Protein 2 |
| Immunogen | A synthesized peptide derived from human TORC2 |
| Gene ID | 200186 |
|---|---|
| Other Names | CREB-regulated transcription coactivator 2, Transducer of regulated cAMP response element-binding protein 2, TORC-2, Transducer of CREB protein 2, CRTC2, TORC2 |
| Name | CRTC2 |
|---|---|
| Synonyms | TORC2 |
| Function | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). |
| Cellular Location | Cytoplasm. Nucleus. Note=Translocated from the nucleus to the cytoplasm on interaction of the phosphorylated form with 14-3-3 protein (PubMed:15454081). In response to cAMP levels and glucagon, relocated to the nucleus (PubMed:15454081) |
| Tissue Location | Most abundantly expressed in the thymus. Present in both B and T-lymphocytes. Highly expressed in HEK293T cells and in insulinomas. High levels also in spleen, ovary, muscle and lung, with highest levels in muscle. Lower levels found in brain, colon, heart, kidney, prostate, small intestine and stomach. Weak expression in liver and pancreas. |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI2213
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