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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-BCAM Rabbit Monoclonal Antibody
KD-Validated Anti-BCAM Rabbit Monoclonal Antibody
Rabbit monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P50895 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 25GB375 |
| Calculated MW | Predicted, 67 kDa, observed, 80 kDa |
| Gene Name | BCAM |
| Aliases | BCAM; Basal Cell Adhesion Molecule (Lutheran Blood Group); F8/G253; CD239; B-CAM; LU; Basal Cell Adhesion Molecule (Lu And Au Blood Groups); B-CAM Cell Surface Glycoprotein; Basal Cell Adhesion Molecule; Auberger B Antigen; F8/G253 Antigen; MSK19; Lutheran Blood Group (Auberger B Antigen Included); Lutheran Blood Group Variant LUGA; Lutheran Blood Group Glycoprotein; B-Cell Adhesion Molecule; Lutheran Antigen; CD239 Antigen; AU |
| Immunogen | A synthesized peptide derived from human BCAM |
| Gene ID | 4059 |
|---|---|
| Other Names | Basal cell adhesion molecule, Auberger B antigen, B-CAM cell surface glycoprotein, F8/G253 antigen, Lutheran antigen, Lutheran blood group glycoprotein, CD239, BCAM, LU, MSK19 |
| Name | BCAM |
|---|---|
| Synonyms | LU, MSK19 |
| Function | Transmembrane glycoprotein that functions as both a receptor and an adhesion molecule playing a crucial role in cell adhesion, motility, migration and invasion (PubMed:9616226, PubMed:31413112). Extracellular domain enables binding to extracellular matrix proteins, such as laminin, integrin and other ligands while its intracellular domain interacts with cytoskeletal proteins like hemoglobin, facilitating cell signal transduction (PubMed:17158232). Serves as a receptor for laminin alpha-5/LAMA5 to promote cell adhesion (PubMed:15975931). Mechanistically, JAK2 induces BCAM phosphorylation and activates its adhesion to laminin by stimulating a Rap1/AKT signaling pathway in the absence of EPOR (PubMed:23160466). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein |
| Tissue Location | Wide tissue distribution (highest in the pancreas and very low in brain). Closely associated with the basal layer of cells in epithelia and the endothelium of blood vessel walls |
Research Areas
Citations (0)
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Application Protocols
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$ 149.00
$ 499.00
Cat# AGI2216
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