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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-MIB1 Rabbit Monoclonal Antibody
KD-Validated Anti-MIB1 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC |
|---|---|
| Primary Accession | Q86YT6 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 25GB420 |
| Calculated MW | Predicted, 110 kDa; observed, 100 kDa |
| Gene Name | MIB1 |
| Aliases | MIB1; MIB E3 Ubiquitin Protein Ligase 1; ZZANK2; DIP-1; DAPK-Interacting Protein 1; KIAA1323; ZZZ6; MIB; Zinc Finger ZZ Type With Ankyrin Repeat Domain Protein; RING-Type E3 Ubiquitin Transferase MIB1; E3 Ubiquitin-Protein Ligase MIB1; DIP1; Mindbomb E3 Ubiquitin Protein Ligase 1; Mindbomb Homolog 1 (Drosophila); Ubiquitin Ligase Mind Bomb; Mind Bomb Homolog 1; EC 2.3.2.27; EC 6.3.2; LVNC7 |
| Immunogen | A synthesized peptide derived from human MIB1 |
| Gene ID | 57534 |
|---|---|
| Other Names | E3 ubiquitin-protein ligase MIB1, 2.3.2.27, DAPK-interacting protein 1, DIP-1, Mind bomb homolog 1, RING-type E3 ubiquitin transferase MIB1, Zinc finger ZZ type with ankyrin repeat domain protein 2, MIB1, DIP1, KIAA1323, ZZANK2 |
| Name | MIB1 |
|---|---|
| Synonyms | DIP1, KIAA1323, ZZANK2 |
| Function | E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis (By similarity). Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation. |
| Cellular Location | Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Cell membrane. Note=Localizes to the plasma membrane (By similarity) According to PubMed:15048887, it is mitochondrial, however such localization remains unclear. Displaced from centriolar satellites in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock. |
| Tissue Location | Widely expressed at low level. Expressed at higher level in spinal cord, ovary, whole brain, and all specific brain regions examined. |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI2219
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