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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-PREB Rabbit Monoclonal Antibody
KD-Validated Anti-PREB Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q9HCU5 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 25GB4240 |
| Calculated MW | P redicted, 45 kDa; observed, 45 kDa |
| Gene Name | PREB |
| Aliases | PREB; Prolactin Regulatory Element Binding; SEC12; Prolactin Regulatory Element-Binding Protein; Guanine Nucleotide-Exchange Factor SEC12; Mammalian Guanine Nucleotide Exchange Factor MSec12 |
| Immunogen | Recombinant protein of human PREB |
| Gene ID | 10113 |
|---|---|
| Other Names | Guanine nucleotide-exchange factor SEC12, Prolactin regulatory element-binding protein, PREB {ECO:0000303|PubMed:10920239, ECO:0000312|HGNC:HGNC:9356} |
| Name | PREB {ECO:0000303|PubMed:10920239, ECO:0000312|HGNC:HGNC:9356} |
|---|---|
| Function | Guanine nucleotide exchange factor (GEF) that regulates the assembly of the coat protein complex II/COPII in endoplasmic reticulum (ER) to Golgi vesicle-mediated transport. Selectively activates SAR1A and SAR1B by promoting the exchange of guanosine diphosphate (GDP) for guanosine triphosphate (GTP) in these small GTPases (PubMed:32358066). In their activated GTP-bound state, SAR1A and SAR1B insert into the membrane of the endoplasmic reticulum where they recruit the remainder of the coat protein complex II/COPII which is responsible for both the sorting of proteins and the deformation and budding of membranes into vesicles destined to the Golgi (PubMed:32358066). |
| Cellular Location | Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9WTV0}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9WTV0}. Nucleus {ECO:0000250|UniProtKB:Q9WTV0} Note=Concentrates at endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER) |
| Tissue Location | Ubiquitous. |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 149.00
$ 499.00
Cat# AGI2247
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